整合遗传学与糖尿病学课程体系之新教学模式探讨 - new century .pdf

/index.php/jenc Journal of Education in New Century,2015,Vol.3,No.2 Exploration of the new teaching mode for the reform in the integration of genetics and diabetology in the learning curriculum systems Li-mei Liu Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, the Sixth Peoples Hospital, Shanghai, China Received: Aug 04, 2015 Accepted: Aug 20, 2015 Published: Dec 31, 2015 DOI:10.14725/jenc.v3n2a1272 URL:/10.14725/jenc.v3n2a1272 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Diabetes is a genetically heterogeneous disease. Therefore, according to its pathophysiological and clinical characteristics, it can be divided into four types: type 1, type 2, other special types and gestational diabetes, which can be also classified into monogenic form and polygenic susceptibility form of diabetes according to mutations or variations in causing genes. As the research progress of molecular genetics, mutated pathogenic genes of familial hereditary diabetes mellitus are gradually clarified, the “precision medicine” time for genetic diagnosis and individualized drug targeted therapy of special types of diabetes, which is functionally characterized by genetic defects of islet β cells with monogenic mutations, has come ! Studies for special types of diabetes, as model of polygenic susceptibility forms of diabetes, will accelerate the latter’s development of precision medicine. Thus, for the teaching system of medical undergraduate students, it is imperative to study the reform in the integration of genetics and diabetology in the learning curriculum systems. Key Words Integration; Genetics; Diabetology; Precision medicine; New teaching mode