孟鲁司特对儿童支气管哮喘肺功能及炎症因子水平的影响.PDF

• 1016 • Drug Evaluation Research 第39 卷 第6 期 2016 年12 月 孟鲁司特对儿童支气管哮喘肺功能及炎症因子水平的影响 刘调侠，李延琴 铜川市妇幼保健院 儿科，陕西 铜川 727007 摘 要：目的 研究孟鲁司特对儿童支气管哮喘的临床疗效、肺功能及炎症因子水平的影响。方法 选择2014 年9 月—2016 年3 月在铜川市妇幼保健院进行诊治的支气管哮喘患儿124 例，随机分为观察组与对照组，每组62 例。对照组给予常规吸 入激素治疗，观察组在对照组基础上加用孟鲁司特钠咀嚼片。治疗3 个月后，观察两组的疗效，进行日夜间症状评分，用酶 联免疫吸附法测定血清中白介素（IL ）-6、IL-8、核转录因子κB （NF-κB ）的水平，用肺功能测试仪检测肺功能。结果 观 察组的有效率为88.71%，明显高于对照组的62.90% （P ＜0.05 ）；治疗后，两组患儿的日夜间症状评分均明显降低（P ＜0.05 ）， 且观察组降低更为明显（P ＜0.05 ）；治疗后，两组患儿的呼气流量峰值（PEF ）、一秒钟用力呼气量 （FEV1 ）、50%肺活量最 大呼气流速 （V ）与25%肺活量最大呼气流速 （V ）均明显升高（P ＜0.05 ），且观察组升高更为明显（P ＜0.05 ）；治疗后， 50 25 两组患儿的IL-6、IL-8、NF-κB 水平均明显降低（P ＜0.05 ），且观察组降低更为明显（P ＜0.05 ）。结论 孟鲁司特对儿童支 气管哮喘具有较好的临床疗效，能明显改善患儿的日夜间症状和肺功能，并降低IL-6、IL-8、NF-κB 水平。 关键词：孟鲁司特；支气管哮喘；临床疗效；肺功能；炎症因子 中图分类号：R969.4 文献标志码：A 文章编号：1674 - 6376 (2016) 06 - 1016 - 04 DOI: 10.7501/j.issn.1674-6376.2016.06.019 Effect of Montelukast on pulmonary function, IL-6, IL-8, and NF-κB in children with bronchial asthma LIU Diao-xia, LI Yan-qin Pediatrics Department, Tongchuan Maternal and Child Health Hospital, Tongchuan 727007, China Abstract: Objective To investigate the clinical effect of Montelukast on pulmonary function, IL-6, IL-8, and NF-κB in children with bronchial asthma. Methods Totally 124 cases of patients with bronchial asthma who were treated in Tongchuan Maternal and Child Health Hospital from September 2014 to March 2016 were selected and divided into two groups randomly. The patients in control group were treated with regular inhaled corticosteroid therapy, and the patients in observation group were treated with Montelukast based on the treatment of control group. After treatment for 3 months, the curative effects, day and night symptom scores, pulmonary functions, IL-6, IL-8, and NF-κB of two groups were observed. Results The effective rate of observation grou