乳腺癌及癌前病变中EphA2 ERβ的表达.pdfVIP

第21卷 第6期 长治医学院学报 V0】．21 No．6 414 2007年 l2月 JOURNAL OF CHANGZHI MEDICAL COLLEGE Dec． 20o7 乳腺癌及癌前病变中．EphA2 E 的表达 秦 艳 梁建芳 郑绘霞 摘 要 目的：通过检测乳腺癌及癌前病变中EphA2蛋白的表达情况，探讨其与E邸表达的关系及 其在乳腺癌发生中的作用。方法：采用免疫组织化学Envision法，检测20例乳腺纤维腺瘤组织、30例乳腺 导管上皮不典型增生组织、35例乳腺导管内癌组织及60例原发性浸润性导管癌组织中EphA2及E邴表 达情况。结果：EphA2蛋白在60例浸润性乳腺癌组织中表达显著高于其余三组(P0．01)。EphA2蛋 白表达与绝经状态、病理分级、临床分期及淋巴结转移相关(P0、05)，E邸表达与绝经状态、病理分级、 及淋巴结转移无关(P0．05)，仅与临床分期有关(P0．05)。乳腺癌中EphA2与E邸的表达呈负相 关关系(P0．05)。结论：EphA2与ERJ3的表达与乳腺癌的发生发展有关。 关键词 免疫组织化学；乳腺癌；EphA2；ERJ3 中图分类号 R392．3 文献标识码 A 文献编号1006一(2007)06—414—04 Expression of EphA2 and ERp in Premalignant Lesion and Carcinonm of Breast Qin Yan，Liang Jianfang，Zheng Huixia Dept ofPathology ￡Clinical Medical College．Shanxi Medical University Abstract Objective：To investigate the expression of the EphA2 and the ERJ3 in premalignant lesion and carcinoma of breast、Methods：The expression of RASSF1A and CyclinD1 were detected by immunohistochemistry in 20 cases fibroadenoma of breast tissues、30 cases duct atypical hyperplasia tissues、35 casG~intraductal carci- noma tissues and 60 cases primarily infitrating ducta1 carcinoma tissues．Results：There were significant difer- ences of EphA2 or ERJ3 expression among four groups(P0．01)．There was statistically difference in the eX- pression of EphA2 in menopause、TNM stage、lymph node metatasis and pathological changes(PO．05)．There Was no statistically difference in the expression of ERG in menopause、pathological changes and lymph node metatasis(P0．05)，but it correlated with the TNM stage(P0．05)．Negative correlation Was found between the expression of EphA2 and ERp in breast cancer．Conclusion：The expression of EphA2 and E邸 may play an important role in breast cancer pathogenesis． Key words Immunohistochemistry；Breast carcinoma；EphA2；ERl3 EphA2(