发病第七天肌钙蛋白I水平在急性心肌梗死患者预测预后中的价值.pdfVIP

· 56 · 江西医学院学报2007年第47卷第6期 Acta Academiae Medicinae Jiangxi 2007，Vol 47，No6 发病第七天肌钙蛋白I水平 在急性心肌梗死患者预测预后中的价值 游志刚，姜醒华，程开诚，吴延庆，苏 海，吴清华，程晓曙 (南昌大学第二附属医院心血管内科，南昌330006) 摘要：目的 探讨发病第7天肌钙蛋白I(cTn1)水平在急性心肌梗死(AMI)患者预测预后中的价值。方法 采用 全自动化学发光免疫分析系统，应用化学发光法测定发病第 7天 cTnl水平。观察 117例 AMI患者主要心血管的 事件(MACE)的发生情况，分析发病第7天cTnl水平与MACE发生的关系。结果 117例AMI患者第7天cTnl 水平明显高于对照组(PO．01)，第7天cTnl转阴率为3O．8 。cTnl≥1．5／~g／L者MACE发生率为35．8％，cT— nI1．5 t~g／L者MACE发生率为2．8％，两者比较，差异有统计学意义(PO．01)。发生MACE者cTnl值明显高 于不发生MACE者(PO．05)。18例延期PCI者无一例发生 MACE。结论 第7天 cTnl阴性者无MACE生存 率高；第7天cTnl阳性者为一高危人群，延期PCI可改善预后。 关键词：心肌梗死，急性；肌钙蛋白I；预后 中图分类号：R542．2 2 文献标识码：A 文章编号：lOOO--2294(2oo7)o6--oo56--o3 CTnI Level at 7 days after AMI is Predictive of the Prognosis of Patients YOU Zhi-gang，JIANG Xing-hua，CHENG Kai-cheng， WU Yan—qing，SU Hai，WU Qing-hua，CHENG Xiao-shu (Department of Cardiovasology，the Second Affiliated Hospital of Nanchang University，Nanchang 330006，China) AB tACT：Objective To investigate whether the serum level of cardiac troponin I(c1 I)at 7 days after acute myocardial infarction(AMI)was predictive of the prognosis of patients．Methods One hundred and seventeen patients with AM1 were included in this program．The levels of cTnI at 7 days after AM1 were measured by chemoluminescence technique．Major cardiovascular events(MACEs)were recorded in admis— sion and follow-up period．We analyzed the correlation between the serum levels of c 1I and the incidence of MACEs according to different therapies，drug or delayed percutaneous coronary intervention(PCI)．Re- suits Compared with those in controls。the levels of cTn1 were significantly increased at 7 days after AMI(PO．O1)．At