支架结构对聚乳酸组织工程支架在SBF溶液中降解进程的影响.pdfVIP

第25 卷 第2期 总第106期 Vol1 25 No 1 2 Journal of Materials Science Engineering Apr. 2007 : 1673- 2812 ( 2007) 02- 0221- 04 SBF 1 2 2 , , ( 1. , 250061; 2. , 510640) = (S F) ,S F : 200-300 1 ( 100 300-400 ) , ; , , S F , = ;; ;S F ; :T 39 :A Influence of Poly( lact c ac d) Scaffold Structure to ts Degradab l ty n SBF 1 2 2 GE J an-hua , WANG Y ng-jun , ZHENG Yu- dong ( 1. Inst tute of Mater al Sc ence and Eng neer ng, Shandong Un vers ty , J nan 250061, Ch na; 2. Inst tute of Mater al Sc ence and Eng neer ng, South Ch na Un vers ty of Technology , Guangzhou 510640, Ch na) = Abstract In the paper, the degradabilities of poly( lactic acid) tissue engineering scaffolds with different pore size and pore ratio were studied to find the influence of poly( lactic acid) scaffolds structure on its degradability in simulated body fluid (S F) . It was found that the performance of scaffolds with mezzo pore size (200-300 Lm) was even and did not change extremely. So, 200-300 Lm was appropriate pore size. At the same time, it was foundthat the bigger the pore ratio was, the slower the rate of materials. molecular weight decrease was and the smaller the lost weight rate of scaffolds was. It was possible that when the pore ratio was small, the transgression of acidic degraded produceswas difficult and they encircled the scaffolds and became the catalyzer of degradation. The weightlessness of scaffolds did not increase with the prolong of degrading time. The reason maybe was that when the scaffolds. materials were degrading, the ions in S F we