异位脉络丛癌（附1例报告及文献复习）.pdfVIP

170 December 2007，Vo1．4，No．4 · 论著 异位脉络丛癌(附1例报告及文献复习) 朱海青，沈静，周金宝，张巧全，梁为俭 【摘要】 目的 介绍脉络丛乳头状癌的病理和免疫组化特征。方法 对一例脉络丛乳头状癌患者的临 床表现、组织形态学和免疫组化染色进行分析，并结合文献对本病的诊断、鉴别要点进行lr探讨。结果 脉络 丛乳头状癌的组织学形态特点：由柱状上皮围绕毛细血管、纤维组织所形成的乳头样结构。瘤细胞有异型，可 见核分裂相。免疫组化示细胞角蛋白(CK)阳性，胶质纤维酸性蛋白(GFAP)、S-100及波形蛋白(Vimentin) 灶性阳性，上皮膜抗原(EMA)、突触素(Syn)、神经元特异性烯醇化酶(NSE)、神经微丝(NF)及均为阴性。 Ki67：20％。PAS染色阴性。结论 脉络丛乳头状癌的诊断主要依靠其组织学形态和免疫组化标记；常需 与室管膜瘤、转移癌及乳头瘤型脑膜瘤鉴别。 【关键词】 脉络丛肿瘤，乳头状癌；免疫组化 【中图分类号】R739．41 【文献标识码】A 【文章编号】1672—7770(2007)04—0170-03 Dystopia choroid plexus tumor ZHU Hal—qing，SHEN Jing，ZHOU Jin—bao，et a1．Department of Pathology， Brain Hospital Affiliated to Nanfing Medical University，Nanjing 210029，China Abstract：0bjective To investigate the opathological and immunohistoehemical features，histogenesis and biologic behaviors of choroid plexus carcinoma．Methods One ease of choroid plexus carcinoma was studied by clinic，histopath~)logic criteria and immunohistoehemieal staining．Literatures were reviewed emphasizing the diagnostic criteria and differential diagnosis．Results The histopathologie features of choroid plexus careinoma were composed of delicate fibrovascular connective tissue frounds covered by a single layer of uniform euboidal to columnar epithelial cells with round or oval nuclei． The tumour shows flank signs ot。malignancy． Mitoses were frequent． Immunohistochemie alanalysis showed that the choroid plexus carcinoma exp!。essed CK，GFAP，S-1 00 and Vimentin were expressed in some cells．The EMA，Syn，NSE and NF were all not expressed．Ki67 labelling was more than 20％ ．PAS stain was not f0und．Conclusions The diagnosis of choroid plexus tumors were made by histopathologie alanalysis and immunohistoehemical staining．The ependymoma，metastatic carcinoma and papillary meningioma are relevant in the differential