2-甲氧基雌二醇通过雌激素受体抑制低氧性肺动脉平滑肌细胞的增殖.pdfVIP

目 录 中文摘要·····································································································1 英文摘要·····································································································4 英文缩写·····································································································7 研究论文 2-甲氧基雌二醇通过雌激素受体抑制低氧性肺动脉平滑肌 细胞的增殖 前言·····································································································8 材料与方法·························································································9 结果····································································································19 附图····································································································20 讨论····································································································28 结论····································································································31 参考文献····························································································32 综述 雌激素及其代谢产物对血管平滑肌细胞作用的相关性研究 ····37 致谢············································································································53 个人简历····································································································54 万方数据 中 文 摘 要 2-甲氧基雌二醇通过雌激素受体抑制低氧性肺动脉平滑肌细胞 的增殖 摘 要 目的：肺动脉高压(pulmonary arterial hypertension, PAH)是以肺动脉压 力升高以及血管中膜增殖重塑、内膜增生为主要特征，从而导致的血管进 行性闭塞的一种疾病，其中以早期的肺动脉收缩反应增强及晚期的血管平 滑肌细胞(Vascular smooth muscle cells, VSMCs)增殖为其主要病理变化， [1] 从而导致肺血管结构重建 。低氧既可以独立地促进 PAH