MyD88、TRAF6在横纹肌溶解致急性肾损伤中的作用及盐酸 戊乙奎醚干预的影响.pdfVIP

目 录 中文摘要·············································································1 英文摘要·············································································4 英文缩写·············································································8 研究论文 MyD88 、TRAF6 在横纹肌溶解致急性肾损伤中的作用及盐酸 戊乙奎醚干预的影响 前言·············································································9 材料与方法····································································11 结果·············································································18 附图·············································································20 附表·············································································30 讨论·············································································32 结论·············································································36 参考文献·······································································37 综述 TLR/MyD88 信号通路与肾脏病········································40 致谢···················································································51 个人简历 ············································································52 万方数据 中 文 摘 要 MyD88 、TRAF6 在横纹肌溶解致急性肾损伤中的作用及盐酸 戊乙奎醚干预的影响 摘 要 目的： 横纹肌溶解症（rhabdomyolysis,RM ）是指由多种原因引起的横纹肌 细胞溶解、破坏，以及肌内容物释放进入血液循环，导致的生化紊乱及多 脏器损伤的临床综合征。近年来，随着生活习惯的变化，由于长跑、进食 小龙虾、醉酒等导致的 RM 发病率明显升高，严重者危及患者生命。肾 脏是RM 最多见的受累器官，急性肾损伤( acute kidney injury，AKI )伴随 RM 整个病程，部分发展至急性肾衰竭的患者由于缺乏有效治疗而不愈。 研究发现炎症反应、氧化应激、Ca2+稳态失调、细胞的毒性作用、活性氧 以及自由基等是其重要病理生理机制，其中炎症反应作为人类绝大多数损 伤性疾病的重要病理机制，在急性肾损伤中的作用尤其受到重视。髓样细 胞分化因子88 （Myeloid ifferentiation