药品包装材料中锡迁移量的石墨炉原子吸收光谱法测定.pdfVIP

JournalofPharmaceuticals ·209· 中国医药工业杂志Chinese 2009，40(3) 一，，，，，，，，，，，，，，，，，，屯 §制药装备与包装≥ ’t‘‘‘‘‘‘‘‘‘‘‘‘‘‘‘‘‘·‘● 药品包装材料中锡迁移量的石墨炉原子吸收光谱法测定 张芳芳，范国荣 (第二军医大学药物分析教研室，上海200433) 摘要：建立了石墨炉原子吸收光谱法测定模拟不同极性(10％乙醇、正庚烷、异辛烷)的浸提条件下药品包装材料中锡的 迁移量。模拟浸提后，挥干有机溶剂，消化回收后测定，用硝酸钙为基体改进剂，3％硝酸为辅助剂。锡在5～25ng／ml低 检测限分别为0．4、O．3和O．7ng／ml。 关键词：石墨炉原。r吸收；锡；药品包装：基体改进剂；测定 中图分类号：TQ460．6+9；657．3l文献标志码：A 文章编号：1001-8255(2009)03—0209-04 DeterminationofStannum LevelinPharmaceuticalMaterial Migration Package with FurnaceAtomic Graphite AbsorptionSpectrometry ZHANG Fang—fang，FANGuo—rong Second Medical 200433) (PharmaceuticalAnalysisStaff,TheMilitary University,Shanghai ABSTRACT：Thefurnaceatomic wasestablishedforthedeterminationof graphite absorptionspectrometry stannum levelin materialindifferentconditions(1 and migrationpharmaceutical polar 0％ethanol，heptane package removalofthe extractionwere nitratewasusedasmatrix isooctane)．After solvent，the samplesdigested．Calcium modifierand wasas calibrationcurveofstannumwaslinearintheconcentrationof HN03 auxiliary．The range5·25ng／ml Was and in (r=0．9995)．The 95．6％，96．2％and98．4％．Thelimitdetectionwas recovery 0．4ng／ml，0．3ng／ml0．7ng／ml and 10％ethanol，heptaneisooctane，respectively． furnaceatomic absorption package；matrixmodif