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针刺治疗Cx43基因敲除鼠胶原性关节炎的免疫学研究.pdf
WormJ．Acu—moxi．Vo1．17，No．4，December，2007 ·27·
E perimental Researchperimental esearch
I UNoLoGICAL STUDY oN ACUPUNCTURE TREATMENT 0lF CoLLA．
GEN-INDUCED ARTHRITIS IN CX43．KNOCK．oUT RATS
针刺治疗Cx43基因敲除鼠胶原性关节炎的免疫学研究
YAN C蛐．q岫(颜灿群) ZIIAN Ke-bin(占克斌) 。HUANG Guang-ying(~ ：)△
。WANG Wei(王 伟)
Department ofEmergency，Shengzhen 5th Peoples Hospital，Guangdong 518001，China(深圳市第五人民
医院急诊科，深圳 518001，中国)； Department ofNeurology，Shengzhen 5th Peoples Hospital，Guangdong
518001，China(深圳市第五人民医院神经内科，深圳 518001，中国)；。Institute of Integrated Chinese and
Western Medicine，Affiliated Tongj Hospital，Tongji Medical College，Huazhong University ofScience and
Technology，Hubei 430030，China(华中科技大学同济医学院附属向济医院中西医结合科，武汉430030，
中国)
ABSTRACT Objective To observe the therapeutic effect of acupuncture for collagen-induced arthritis(CIA)
in Cx43 knock-out mice and its underlying immunological mechanism．Methods Heterozygote(Cx43+／-)
mice(n=64)and wild-type(Cx43 十)mice(n=46)were used in the present studv．CIA mode1 was es—
tablished by intracutaneous injection of bovine collagen II(immunonization)．Acupuncture of Zfis~nli(足三里
ST36)was carried out from the 4们week on after the initiaIimmunization，once a day f0r 3 weeks．Arthritis
score and days of onset of CIA were recorded．Intracellular contents of Th subgroups of splenic lymphocytes
were detected with flow cytometry．Results The incidence rate of CIA and arthritis score in Cx43 一mice
were significantly Iower than those in Cx43 mice (P0．05)．In Cx43十 十mice，3 wccks after acupunc—
ture treatment，the score of arthritis symptoms and signs in acupuncture group was significantly lower than
that in modeI group(P0．01)，while in 0x43 一mice，no significant difference was found between modeI
group and acupuncture group in arthritis score(PO．05)．In comparison with control group，percentages of
both Thl and Th2 and Thl／Th2 increased significantly in Cx43 十CIA model group(P0．05)，while com
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