生物信息学两两序列比对概要1.ppt

PAM matrices are based on global alignments of closely related proteins. The PAM1 is the matrix calculated from comparisons of sequences with no more than 1% divergence. At an evolutionary interval of PAM1, one change has occurred over a length of 100 amino acids. Other PAM matrices are extrapolated from PAM1. For PAM250, 250 changes have occurred for two proteins over a length of 100 amino acids. All the PAM data come from closely related proteins (85% amino acid identity). PAM matrices: Point-accepted mutations Page 63 Dayhoff’s PAM1 mutation probability matrix Page 66 Dayhoff’s PAM0 m