蛋白-蛋白相互作用小分子抑制剂研究进展 - 上海有机化学研究所.pdf

See discussions, stats, and author profiles for this publication at: /publication/236231966 Progress in Small Molecular Inhibitors of Protein-Protein Interactions Article in Chinese Journal of rganic Chemistry · November 2010 CITATI NS READS 0 163 4 authors, including: Jian Min Pengcheng Wang University of Illinois, Urbana-Champaign University of California, Riverside 20 PUBLICATI NS 56 CITATI NS 34 PUBLICATI NS 60 CITATI NS SEE PR FILE SEE PR FILE Some of the authors of this publication are also working on these related projects: F XM1 inhibitors as potential therapeutics in breast cancer , development of novel Selective Estrogen Receptor Downregulators (SERDs) as therapeutics in estrogen receptor positive breast cancer View project All content following this page was uploaded by Pengcheng Wang on 09 July 2017. The user has requested enhancement of the downloaded file. 2010 年第 30 卷 有 机 化 学 Vol. 30, 2010 第 11 期, 1778～1789 Chinese Journal of Organic Chemistry No. 11, 1778～1789 ·学术动态· 蛋白-蛋白相互作用小分子抑制剂研究进展 闵 鉴 汪鹏程 董春娥 周海兵* (武汉大学药学院 病毒学国家重点实验室 武汉 430071) 摘要 蛋白-蛋白相互作用在生物过程中扮有非常重要的角色, 并且与人类疾病息息相关. 因此, 基于蛋白-蛋白相互 作用的小分子抑制剂的研究为新药研发提供了更好的思路与方向. 对近几年来合成的几类蛋白-蛋白相互作用小分子 抑制剂的设计、化学结构、生物活性及研究进展进行了较为详细的综述, 对其发展趋势进行了展望. 关键词 蛋白-蛋白相互作用; 小分子抑制剂; 药物设计; 化学生物学; 研究进展 Progres