天舒滴丸对急性血瘀模型大鼠血液流变学和血栓形成的影响.pdf

现代药物与临床 Drugs Clinic 第 29 卷 第 5 期 2014 年 5 月 ·471 · 天舒滴丸对急性血瘀模型大鼠血液流变学和血栓形成的影响 张 红 1, 2, 3，曹 亮 1, 2, 3，李 娜 1, 2, 3，唐朝辉 1, 2, 3 ，丁 岗1, 2, 3，王振中 1, 2, 3，萧 伟 1, 2, 3* 1. 江苏康缘药业股份有限公司，江苏 连云港 222001 2. 中药制药过程新技术国家重点实验室, 江苏 连云港 222001 3. 江苏省企业院士工作站，江苏 连云港 222001 摘 要：目的 研究天舒滴丸对急性血瘀模型大鼠血液流变学、血小板聚集及血栓形成的影响。方法 SD 大鼠随机分为对 照组、模型组、天舒胶囊（4.0 g/kg ）组、天舒滴丸（1.0、2.0 、4.0 g/kg ）组，ig 给药 3 d 后，采用肾上腺素配合冰浴制备大 鼠急性血瘀模型，分别测定全血黏度，血浆黏度，红细胞压积，血沉，体外形成血栓的长度、湿质量、干质量，血小板聚集 率等指标。结果 天舒滴丸能明显降低急性血瘀模型大鼠全血和血浆黏度，明显降低血栓长度、血栓湿质量和干质量，抑制 模型大鼠血小板聚集率的升高。结论 天舒滴丸能够改善急性血瘀模型大鼠血液流变性，抑制血小板聚集及血栓形成。 关键词：天舒滴丸；偏头痛；血液流变学；血小板聚集；血栓 中图分类号：R285.5 文献标志码：A 文章编号：1674 - 5515(2014)05 - 0471 - 05 DOI: 10.7501/j.issn.1674-5515.2014.05.005 Effects of Tianshu Dropping Pill on hemorheology and thrombosis in acute blood stasis model rats ZHANG Hong1, 2, 3, CAO Liang1, 2, 3, LI Na1, 2, 3, TANG Zhao-hui1, 2, 3, DING Gang1, 2, 3, WANG Zhen-zhong1, 2, 3, XIAO Wei1, 2, 3 1. Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China 2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China 3. Jiangsu Enterprise Academician Workstation, Lianyungang 222001, China Abstract: Objective To study the effects of Tianshu Dropping Pill on hemorheology, thrombosis, and platelet aggregation in acute blood stasis model rats. Methods The mice were divided into six groups such as control, model, Tianshu Capsule (4.0 g/kg), and Tianshu Dropping Pill (1.0, 2.0, and 4.0 g/kg) groups. After ig administration for 3 d, the acute blood stasis rat model was established by sc injection of adrenaline hydrochloride and being socked in ice-water. Viscosity of blood and plasma, erythrocyte sedimentation, hematocrit, rates of platelet aggregation, and wet weight, length, and dry weight of thrombosis formed in vitro were d