肝母细胞癌中CD13预后意义（基础研究）.pdfVIP

bs_bs_banner Pediatrics International (2015) 57, 558–566 doi: 10.1111/ped.12597 Original Article Prognostic significance of aminopeptidase-N (CD13) in hepatoblastoma Satoshi Saida,1 Ken-ichiro Watanabe,1 Itaru Kato,1 Hisanori Fujino,1 Katsutsugu Umeda,1 Shinya Okamoto,2 Shinji Uemoto,2 Tomoro Hishiki,6 Hideo Yoshida,6 Shiro Tanaka,3 Souichi Adachi,5 Akira Niwa,4 Tatsutoshi Nakahata4 and Toshio Heike1 1Department of Pediatrics, 2Division of Hepato-pancreato-biliary Surgery and Transplantation, 3Division of Clinical Trial Design and Management, Translational Research Center, Kyoto University Graduate School of Medicine, 4Department of Clinical Applications, Center for iPS Cell Research and Application (CiRA), Kyoto University, 5Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, and 6Department of Pediatric Surgery, Chiba University Graduate School of Medicine, Chiba, Japan Abstract Background : Hepatoblastoma is a rare childhood malignant tumor that originates from immature hepatic cells. Aminopeptidase-N(CD13), an ectopeptidase that promotes tumor invasion and metastasis, is expressed in fetal stage hepatic progenitor cells, although its role in hepatoblastoma remains unclear. Methods : The expression pattern of CD13 was investigated on immunohistochemistry in 30 tissue samples from 27 hepatoblastoma patients (16 with predominantly embryonal [pE] histology and 14 with predominantly fetal [pF] histology). Immunoreactive score (IRS) was used to quantify staining data, and the relationship between CD13 expression, clinicopathological factors, a