正常人海马质子磁共振波谱研究.pdfVIP

· 774 · 四川医学2008年6月第29卷(第6期) SichuanMedical Journa1．2008，Vo1 ． 29，No．6 ●影像医学● 论著 正常人海马质子磁共振波谱研究 黄海东，顾建文，杨春敏，赵 凯，夏 勋，杨文涛 (成都军区总医院，神经外科，放射科，四川成都610083) 【摘要】 目的 运用质子磁共振波谱( H—MRS)研究年龄对正常人海马脑组织代谢物浓度的影响。方法 对8O例 健康成人双侧海马进行 H—MRS检测，对比分析不同年龄组的海马N一乙酰基天门冬氨酸(NAA)／肌酸复合物(Cr)和含胆 碱化合物(Cho)／Cr比值的变化。结果 随着年龄的增长，在≤5O岁年龄段海马的NAA／Cr和Cho／Cr比值无明显改变，但 在50岁年龄段海马的NAA／Cr比值逐渐降低、Cho／Cr比值逐渐增高。结论 H—MRS是可以为正常人海马与年龄相关 的代谢物浓度的改变提供有价值的信息的一种无创技术。 【关键词】 正常人；质子磁共振波谱；海马 【中图分类号】 R 445．2 【文献标识码】 A 【文章编号】 1004—0501(2008)06—0774—03 Study of proton magnetic resonance spectroscopy in hippocampus of normal human．HUANG Hai·dong，GU~ian-wen，YANG Chun-min，et a1．General Hospital ofChengdu Military Command，Chengdu，Sichuan 610083，China 【Abstract! Objective To explore the effect of age on hippocampus metabolite concentrations in normal human using proton magnetic resonance spectroscopy( H—MRS)．Methods H—MRS localized to the both hippocampus，was carried out in 80 healthy volun— teers．The metabolite ratios of N—acetylasparatate(NAA)／creatine(cr)，and choline—containing compounds(Cho)／Cr in different age groups were compared and analysed．Results No significant age—associated changes in hippocampus NAA／Cr and Cho／Cr ratios were observed under 50 age groups．However，hippocampus NAA／Cr ratios wen decreased gradually with age and Cho／Cr ratios were in— creased gradually with age over 50 age groups．Conclusion H—MRS is a noninvasive technique that can provide useful information con— cerning the age—associated changes of hippocampus metabolite concentrations in normal human． 【Key words】 normal human；proton magnetic resonance spectoscopy；hippo