骨质疏松与一氧化氮.pdf

174 Chinese Journal of Pathophysiology 2001, 17(2) : 174- 179 [ ] 1000- 4718(2001)02- 0174- 06 1 1 2 李 昂, 萧劲夫, 薛 延 1 2 ( , 518033; , 100035) Osteoporosis and nitric oxide 1 1 2 LI Ang , XIAO Jin- fu , XUE Yan 1 ( ShenzhenHospital of Traditional Chinese Medicine , Shenzhen 518033, China; 2 Beij ing JishuitanHospital, Beij ing 100035, China) [ A Review] ecent work has shown that nitricoxide (NO) induction by nitricoxide synthase(NOS) is the physiological mediator of bone cellfunction and demonstrated that it may bepossibleto exert differential ef fects on osteoblast (OB) and osteoclast (OC) activity in vivo. The proinflammatory cytokines, such as tumor necrosis factor- (TNF- ) , interleukin- 1(IL- 1) , interferon- ( IFN- ) , will stimulate bone re sorption by NOS- induced low levels of NO. Thesefindings confirm NO as a potentially important osteoblast- osteoclast coupling factor, indicating that cytokine- induced NO was largely responsible for the mechanisms of osteoporosis. Pharmacological modulation of NO may therefore represent a new approach in the treatment of bone diseases characterized by increased bone resorption, such as osteoporosis (OP) . [] ;; ; [MeSH] Osteoporosis; Nitric oxide; Osteoblasts;Osteoclasts + [] 363. 1 4 [] A (nitric oxide,NO) , [2] , cNOS , iNOS ,, ( lipopolysaccharide, LPS) , ,iNOS (