安理申和恩必普联合应用治疗老年性痴呆的研究.pdfVIP

重庆医学2008年4月第37卷第7期 7O1 · 论 著 · 安理申和恩必普联合应用治疗老年性痴呆的研究 邓 娟，许志强，高长越，张 猛，王延江，周华东△ (第三军医大学大坪医院野战外科研究所神经内科，重庆400042) 摘 要：目的 探讨联合应用安理申和恩必普对老年性痴呆患者认知功能和行为能力的改善作用。方法 收集老年性痴呆 患者 180例，随机分为3个组：安理申和恩必普联合治疗组6O例，安理申治疗组 6O例，对照组6O例。对照组不使用防止痴呆药 物。3组患者分别在治疗前和治疗3、6个月后进行 MMSE评分、ADI 评分的测评。结果 安理申和恩必普联合治疗组患者治疗 后认知、行为能力较安理申治疗组改善明显(P0．01)。结论 安理中和恩必普联合治疗对老年性痴呆患者认知、行为能力有显 著改善作用。 关键词：安理申；恩必普；老年性痴呆；认知功能 中图分类号：R749．16；R971 文献标识码：A 文章编号：1671—8348(2008)07—0701—02 Clinical observation on effect of combination of donepezil and butylphthalide in treating old patients with alzheimer S disease DENGJuan，XUZhi—qiang，GAOChang—yue，et a1． (Department of Neurology，Daping Hospital，Third Military Medical University，Chongqing 400042，China) Abstract：Objective To investigate the effect of combination of donepezil and butylphthalide in treating old patients with Alzheimer S disease on cognitive function and behaviora1．Methods 18O patients with Alzheimer S disease were randomly divided in— to 3 groups：the group treated with donepezil，the group treated with donepezil and butylphtha¨de，the control group treated without any medcine or herb tO prevent Alzheimer S disease．MMSE Scale and ADI Scale of 3 groups were assessed and compared before treatment and 3 months，6 months after treatment．Results The cognitive function and behavioral abilities were improved markedly in the group treated with donepezil and butylphthalide(P0．01)．Conclusion Combination of donepezil and butylphthalide can markedly ameliorate the cognitive function and behavioral abilities in patients with Alzheimer S disease． Key words： donepezil；butylphthalide；cognitive；function 安理申治疗轻、中度老年性痴呆，改善患者认知功能和生 1．2．1 认知功能 采用MMSE评价患者治疗前后的定向力、 活能力的作用已得到肯定[1]，恩必普可以增加缺血区脑