5.15 白血病、淋巴瘤.pptVIP

Etiology Virus: EBV Helicobacter pylori (MALT lymphoma) Defected immunological function Pathology and classification Hodgkin’s disease: NLPHL:结节性淋巴细胞为主型HL CHL：经典型HL 1. Lymphocyte predominance 2. Nodular sclerosis 3. Mixed cellularity 4. Lymphocyte depletion Pathology and classification Non-Hodgkin’s disease: Hopping spread Multi-center origins Lymph node structure damage Classification for NHL WHO Classification 1982 WHO Classification 2000 Indolent lymphoma, aggressive lymphoma SLL, mantal cell lymphma, MULT, DLBCL 2008 WHO将DLBCL分为三大类型 DLBCL亚型 富于T细胞/组织细胞DLBCL 原发性CNS DLBCL 原发性皮肤DLBCL，腿型