凌笑梅教授博士生导师.doc

凌笑梅 教授 博士生导师 单 位：北京大学药学院化学生物学系药物分析教研室E-mail：pkulxm@126.com电 话：010O）；010L）传 真：010　 主要科研方向：药物分析 多年来一直从事仪器分析和药物分析的教学和科研工作，主编了《高等仪器分析实验与技术》，并担任中国药学会药物分析委员会委员、药物分析杂志编委。对色谱联用技术和高效毛细管电泳在医药领域中的应用做了大量的研究工作，主要研究工作有：（1）临床前药物代谢动力学研究；（2）建立新药质量标准；（3）生物分子之间的相互作用及生物分子与药物分子之间相互作用研究；（4）天然产物及合成化合物中活性成分的定性定量筛选研究；（4）手性药物拆分测定；（6）体内、体外脂肪酸含量测定等。发表论文60余篇，近几年以第一作者和责任作者发表的主要代表性论文有： Study on steady-state kinetics of nucleotide analogues incorporation by non-gel capillary electrophoresis, Electrophoresis, 2009, in press Simultaneous determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride and its major metabolite in rats by high-performance liquid chromatography, Journal of Chromatography Science, 2009, in press Interactions Between Thrombin and Natural Products of Millettia nitita var. hirsutissima Using Capillary Zone Electrophoresis, Journal of Chromatography B, 2009, 877: 4107-4114 Determination of anti-tumor agent TM208, 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride, in rats by LC, Chromatographia, 2009, 70: 1721-1725 Capillary electrophoresis for screening of 20S proteasome inhibitors, Analytical Biochemistry, 2009, 394(11): 62-67 Interactions of the peptides from secreted human CKLF1 and the N-terminal extracellular tail of CCR4 analyzed by capillary zone electrophoresis, Chromatographia, 2009, 70(1/2): 287-292 Advances of methods of protein immobilization on capillary, Chinese Journal of Analytical Chemistry, 2009, 37(6): 929–934. Determination of Chloride 3-Methyl-9-(2-oxa-2k5-2H-1,3,2-Oxazaphosphorine-Cyclohexyl)-3,6,9-Triazaspiro [5.5] Undecane (SLXM-2) in Rats by LC:Application to a Pharmacokinetic Study, Chromatographia, 2009, 69(1-2): 111-115 Interactions between thrombin and natural products of Millettia speciosa Champ. using capillary zone, Electrophoresis, 2008, 29(16): 3391-3397 Analysis of the interactions between the peptides from secreted human CKLF1 an