两种常用数量性状连锁分析方法的原理和进展.pdfVIP

遗 　传 HER EDI TA S ( Beijin g) 26 (2) :253～256 ,2004 专论与综述 两种常用数量性状连锁分析方法的原理和进展 宿少勇 ,顾东风 ( 中国医学科学院 中国协和医科大学 阜外心血管病医院 群体遗传与人群防治研究室,北京 100037) 摘 　要 :在复杂性状疾病的家系连锁研究中 ,HasemanElston 回归分析和方差组成模型是常用的两种数量性状连锁 分析方法。前者主要针对同胞对的性状值差或和的平方进行回归分析 ;后者引用方差组成模型 ,将数量性状分解 为遗传方差和环境方差 ,可估计二者对表型的影响。两种方法可应用于同胞对、核心家系或扩展家系 ,定位数量性 状基因座。此文对这两种模型的原理、算法及其进展进行了综述 ,并给出了常用的统计软件包。 关键词 :复杂性状疾病 ;非参数连锁分析 ;数量性状 ; HE 模型 ;方差组成模型 ( ) 中图分类号:Q987 　　　文献标识码 :A 　　　 文章编号 :0253 - 9772 2004 02 - 0253 - 04 Two Approaches of QuantitativeTrait Linkage Analysis SU ShaoYong , GU DongFeng ( Division of Population Genetics and Prevention , Cardiovascular Instit ute Fu W ai Hospital , ) Chi nese Academy of Medical Sciences Peki ng U nion Medical College , Beiji n g 100037 , Chi na Abstract :In this article , we discussed two modelfree methods for detecting genetic linkage for quantitative traits , Hase manElston regression approach and variance components approach. The former is a regression approach for detecting link age based on the squared difference or squared sums in quantitative trait values of sibpairs and their estimated marker IBD scores. The latter can jointl y model covariate effects along with variance components , including genetic component and nongenetic sources of variability. We have outlined the model assumption , the algorithm and the extensions for the both