分子医学所现有研究员的研究领域与经历介绍 一、principal .doc

分子医学所现有研究员的研究领域与经历介绍 一、Principal Investigator：肖瑞平（Rui-Ping Xiao） Personal Synopsis Rui-Ping (Ping) Xiao was trained as a cardiologist and physiologist at Tong-Ji Medical University in?Wuhan,?China and the?Medical School at University of Maryland at Baltimore (UMAB), where she earned her M.D. in??1984 and Ph.D. in 1995, respectively. She joined the Laboratory of Cardiovascular Science, National Institute of Aging, in 1990 as a postdoctoral fellow, and later in 1996 became a tenure-track investigator and the head of the Receptor Signaling Unit. In 2004, she was converted to Senior Investigator at National Institute of Health, USA. She is now a Senior Investigator and co-PI of the Laboratory of Cellular Signaling Network at IMM, PKU. Research Interest The scope of??her research work covers three intertwined programs: (I)??-adrenergic receptor subtype signaling in cardiovascular system;? (II) Modulation of cardiac excitation-contraction coupling by Ca/calmodulin-dependent protein kinase II (CaMKII) in normal and failing hearts;? and (III) Identification and characterization of cardiovascular disease-related genes.?? Her main scientific focus has been G-protein coupled receptor (GPCR) signaling in the cardiovascular system. Using?interdisciplinary approaches, including?physiological and?pharmacological techniques in conjunction with genetic manipulations (e.g. gene-targeted animal models or adenoviral gene transfer systems),?her work?revealed dual coupling of ?2-adrenergic receptor (b2AR) with two functionally opposite G-protein families, Gs and Gi proteins. This counterintuitive finding was the first demonstration that a given GPCR can couple to more than one class of G-proteins in a physiological context?such as in intact cardiac myocytes. Dr. Xiao’s research has demonstrated that the additional Gi coupling creates a microscopic compartmentalization of the concurrent Gs-cAMP signaling and, more importantly, dictates the opposing outcomes of ?AR subtype stimulation