四种方法治疗新生儿缺氧缺血性脑病对比分析.doc

四种方法治疗新生儿缺氧缺血性脑病对比分析【摘要】目的:比较不同治疗方法对中重度新生儿缺氧缺血性脑病(HIE)患儿的效果。方法:将我院2005年6月至2009年12月收治的240例HIE患儿随机分为4组,每组60例:①组(对照组)60例,给予止惊、脱水、维生素C、能量合剂及二磷胆碱等治疗;②组(常规组)60例,上述治疗加用丹参和丽珠塞乐;③组(纳洛酮组)60例,除上述治疗外,加用纳洛酮;④组(高压氧组)60例,在对照组的基础上加用高压氧。结果:四种疗法疗效存在明显差异。结论:高压氧治疗是最有效的疗法,而且远期疗效更好,值得推广应用。 【关键词】新生儿;缺氧缺血性脑病;高压氧 【中图分类号】R722.7 【文献标识码】B 【文章编号】1008-6455(2010)08-0031-01 【Abstract】Objective: To compare the different treatment effect of moderate to severe neonatal hypoxic ischemic encephalopathy (HIE) of children. Methods: 240 patients of HIE collected from From June 2005 to December 2009 our hospital were randomly divided into four groups, each with 60 cases: 60 cases as ①group(control group),only treated with panic, dehydration, vitamin C,Energy mixture of phosphorus and choline, and other treatment;②group (conventional group), 60 cases, the treatment of① plus Salvia and Rachel Cypriot music; ③(naloxone),60 cases, in addition to the above treatment, plus with Luo ketone; ④ (HBO),60 cases to treat with HBO on the basis of control group. Results: there are significant differences among the effect of the- rapy. Conclusion: The high-pressure oxygen therapy is the most effective therapy, and has a better long-term effect. It should be applied widely. 【Key words】newborns;hypoxic ischemic encephalopathy;HBO 新生儿缺氧缺血性脑病(HIE)是新生儿期常见病之一,是新生儿期死亡及婴幼儿神经系统功能障碍,如脑瘫、癫痫发作及智力低下等的主要原因,在预防、诊断及治疗三个层面早期干预可降低此病的发生率、病残率及死亡率[1]。本院2005年6月至2008年12月收治的240例HIE患儿,现报告如下。 1 资料与方法 1.1 一般资料:240例患儿的诊断均符合新生儿缺氧缺血性脑病的诊断标准[2]。胎龄32～45周,日龄0.05);③组和①组、②组均存在显著差别(P 1