小分子非编码rna 与雄性不育.pdf

生物技术通报 ·综述与专论· BIOTECHNOLOGY BULLETIN ( ) 2016, 32 1 :33-40 小分子非编码 RNA 与雄性不育 廖珂  柴志欣  钟金城 - （西南民族大学 动物遗传育种学国家民委 教育部重点实验室 西南民族大学青藏高原研究院，成都 610041） 摘 要 ： 小分子非编码RNA（Small non-coding RNA，sncRNA）是一类20-30 个左右核苷酸长度的RNAs，不具有编码蛋白 质的功能，但在调控机制方面具有广泛的生物学功能。在动物精子形成过程中有两类sncRNAs， 即miRNAs 和piRNAs 起着重要调 控作用，它们在动物睾丸组织中表达异常会导致精子生成障碍从而表现出雄性不育性状。综合分析了sncRNA 的结构、功能以及 对雄性动物生育能力的影响，以期为进一步研究sncRNA 的调控机制提供参考。 关键词 ： 小分子非编码RNA ；精子形成 ；雄性不育 DOI ：10.13560/ki.biotech.bull.1985.2016.01.007 - Small Non coding RNA and Male Sterility - - LIAO Ke CHAI Zhi xin ZHONG Jin cheng （Key Laboratory of Animal Genetics and Breeding of State Ethnic Affairs Commission and Ministry of Education ，Southwest University for - Nationalities ，Institute of Qinghai Tibetan Plateau ，Southwest University for Nationalities ，Chengdu 610041 ） Abstract: Small non-coding RNA（sncRNA）is a kind of RNA with 20-30 nucleotides, and does not have the function of encoding proteins, but has extensive biological functions in terms of regulatory mechanism. In the process of animal sperm formation there are two types of sncRNAs, namely miRNAs and piRNAs playing a critical regulatory role. When they are expressed abnormally in testicular tissues of animals, which causes the production of sperms in obstacle, so as male sterility would appear. In this paper, we summarize sncRNA’s structure and function, and effects on male fertility in order to offer the references for the furthe