还原响应型药物载体的研究进展recent progress in the - 药学学报.pdf

1032 药学学报 Acta Pharmaceutica Sinica 20 11, 46 (9) : 1032 1038 还原响应型药物载体的研究进展 * 唐忠科, 熊兴泉, 蔡 雷, 徐源鸿 (华侨大学材料科学与工程学院, 福建省高校功能材料重点实验室, 福建 厦门 361021) 摘要: 还原响应型药物载体以其高效快速释放药物、毒副作用小、可生物降解的优良特性, 逐渐成为药物载 体领域研究的热点, 也是最具临床应用潜力的智能药物载体之一。本文综述了还原响应型药物载体研究的最新 进展, 包括还原响应的药物、基因与载体的偶联物及还原响应的纳米聚合物胶束、纳米囊泡、纳米中空微球、 纳米脂质体等的合成和药物释放的机制以及各类载体的优缺点, 为其在药剂学中的进一步应用提供理论依据。 关键词: 还原响应; 药物载体; 二硫键; 药物释放 中图分类号: R943 文献标识码:A 文章编号: 05 13-4870 (20 11) 09-1032-07 Recent progress in the study of reduction-sensitive drug carriers * TANG Zhong-ke, XIONG Xing-quan , CAI Lei, XU Yuan-hong (College of Materials Science and Engineering, Huaqiao University, Key Laboratory for Functional Materials of Fuj ian Higher Education, X iamen 361021, China) Abstract: With rapid and efficient drug release, few side effects and excellent biodegradable properties, the reduction-sensitive carriers is not only the new hot point in the field of pharmaceutical research, but also the most promising intelligent drug carrier on clinical application . This paper reviews the latest research of reduction- sensitive drug and gene carriers, including the mechanisms of drug release and the synthesis of the reduction- sensitive conjugates, reduction-sensitive nano polymer micelles, nano vesicles, nano hollow microspheres, nano liposomes, as well as the characteristics and advantages of various kinds of carrier system. It will provide a theoretical basis for its further application. Key wor