不同剂量阿托伐他汀对老年人降脂的疗效和安全性 - 中华医学会.doc

不同剂量阿托伐他汀对老年人降脂的疗效和安全性 程天一1 王俊2 （ 1.黄浦区打浦桥街道社区卫生服务中心 2.龙华街道社区卫生服务中心） 摘要:目的 使用不同剂量的阿托伐他汀对老年人高脂血症的疗效和安全性。方法 选择高脂血症老人153例作为研究对象，随机分为阿托伐他汀低剂量组（10mg/d，A组）79例和常规剂量（20mg/d，B组）74例，分别在治疗前及治疗后2周、8周采集空腹静脉血，分析二组间治疗前后的血脂的差异、疗效以及对肝、肾、肌肉的毒副作用。结果（1）二组中TC、LDL-C经不同剂量阿托伐他汀治疗后均有下降，在统计学上有差异（P0.01），而二组之间对血脂下降无统计学差异（P0.05）。A、B组血脂下降率在治疗8周后，总胆固醇分别为19.6%、20.0%，低密度脂蛋白21.8%、21.5%（P0.05）。（2）A、B二组服用药物后对肝、肾、肌肉的副作用，在统计学无差异（P0.05）。（3）A、B二组服药后尿酸较治疗前均下降，统计学上有差异（P0.01），而二组之间无明显统计学差异（P0.05）。结论 ①10mg/d与20mg/d口服阿托伐他汀同样可使老年人血胆固醇及低密度脂蛋白胆固醇下降。②与20mg/d阿托伐他汀相比，10mg/d口服无明显肝肾、肌肉毒副作用。③A、B组在降脂同时还有降低血尿酸水平，对于老年人的降脂作用是安全有效的。 关键词：阿托伐他汀 高血脂血症 副作用 老年 Efficacy and Safety of Different Dose Atorvastatin on Decreasing Blood Lipid in Elder Patients Cheng Tian Yi , WangJun (Da Pu Community Health Center, Long Hua Community Health Center.) [Abstract]Objective To investigate the efficacy and safety of different dose atorvastatin on hyperlipiemia in edder patients . Methods Choose 153 elder patients on hyperlipiemia in hospital. Above patients were randomly into two groups. A group (n=79)，25 males and 54 females aged 81.24±5.49 years received 10mg/d atorvastatin, B group，24males and 50 females aged 80.91±5.01 years took 20mg/d atorvastatin. Before treatment and After 2weeks and 8 weeks, The level of blood lipid、Functions of liver and kidney、Creatine kinase、 Creatin kinase isoenzymes were investigats. Results (1).After treatment ,The level of TC[cholesterol] reduce 19.6%(A)、20.0%(B)in two groups. LDL[low density lipopro-tein cholesterol] decrease 21.8%（A）、21.5% (B)in both groups. (2) The level of TC、 LDL in two groups have no difference after treatment.（P0.01）.The medicine has no Lesion in liver 、kidney function and myolysis in two groups（P0.05）.（3）After took medicine，The level of Uric acid(UA ) also decreased after treatment in two groups(P0.01) . There is no difference in two groups.(P0.05).Conculsion The lower atorvastatin can not only lower the lipid in eld