囊胚培养能够筛选出发育潜能上乘的胚胎可提高每个移植周期的妊娠率.docVIP

玻璃化冷冻囊胚复苏移植与新鲜囊胚移植的临床结局比较摘要 　目的比较新鲜囊胚移植周期与玻璃化冷冻囊胚复苏移植周期的临床结局。方法 回顾性分我院生殖中心完成的874例囊胚移植周期，其中280例新鲜囊胚移植周期（A组），594例冻融囊胚复苏移植周期（B组），比较两组临床妊娠率、种植率、妊娠结局及新生儿情况等各项指标。结果1. A组平均移植胚胎数显著高于B组，分别为1.88±0.47和1.70±0.53个；临床妊娠率及种植率A组显著低于B组(P0．05)，分别为43.93%，24.96%和55.39%，40.51%。2. A组和B组的流产率、早产率、孕龄、单胎率、多胎率分别为13.82%、32.46%、（265.49±14.45）d、70.16%、29.84%和16.72%、33.84%、（264.43±16.08）d、71.86%、28.14%，均无统计学差异(P0．05)。两组中仅B组见一例异位妊娠，而A组无异位妊娠。3. A组和B组巨大儿、生长受限发生率及新生儿出生缺陷分别为6%、19.66%、1.7%和9.4%、17.82%、0.9%，两组间无统计学差异。结论 玻璃化冷冻囊胚复苏移植显著提高了囊胚移植的种植率及妊娠率，且并没有增加新生儿出生缺陷、流产率、早产率，也没有增加巨大儿和新生儿生长受限的出生比率。因此，玻璃化冻融囊胚移植技术是安全有效的，在临床上值得应用推广。Comparison of clinical outcomes between vitrified-thawed blastocyst transfer and fresh blastocyst transfer. Abstract Objective: The aim of this study was to compare fresh blastocyst transfer with vitrified-warmed blastocyst transfer. Methods: From 2009 to 2011，a total of 874 cases of blastocyst transfer cycles were performed in our center，including 280 cases of fresh blastocyst transfer (group A), and 594 cases of vitrified-warmed blastocyst transfer (group B). Meanwhile a retrospective analysis was performed between two groups with clinical pregnancy rate, implantation rate, pregnancy outcomes and neonatal status. Results: The number of transferred embryos in A group（1.88±0.47） was higher than that of B group（1.70±0.53）, and the clinical pregnancy rate and implantation rate of A group was significantly lower than that of B group（43.93%，24.96% and 55.39% , 40.51%，respectively, P0.05）. 2. No statistical differences were found in rate of abortion, premature delivery rate, gestational age, pregnancy rate, multiple pregnancy rate between A group（13.82%，32.46%，265.49±14.45d，70.16%，29.84%，respectively）and B group（16.72%，33.84%，264.43±16.08d，71.86%，28.14% ，respectively）. In B group there was only one case of ectopic pregnancy, while in A group no ectopic pregnancy. 3. There were no statistical differences in macrosomia, growth restriction and the rate of birth defect between A grou