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2012-Interaction of chlorhexidine with biomembrane models on glass ionomer by using the Langmuir–Blodgett technique.pdf

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Colloids and Surfaces B: Biointerfaces 97 (2012) 57–61 Contents lists available at SciVerse ScienceDirect Colloids and Surfaces B: Biointerfaces j o u r n a l h o m e p ag e: w w w. elsev /locate/cols urfb Interaction of chlorhexidine with biomembrane models on glass ionomer by using the Langmuir–Blodgett technique Bruno L.P. Costalonga a , Renata C. da Silva b , Luciano Caseli a , Celso Molina a,∗ a Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, SP, Brazil b Curso de Odontologia, Universidade Camilo Castelo Branco, São Paulo, SP, Brazil a r t i c l e i n f o a b s t r a c t Article history: The antimicrobial property of chlorhexidine is believed to be associated with its interaction of bacterium Received 8 February 2012 membrane, which calls for research on the identiﬁcation of membranes sites capable of drug binding. In Received in revised form 14 March 2012 this study, we investigated the interaction of chlorhexidine digluconate, a known agent with bactericidal Accepted 19 March 2012 and bacteriostatic activities employed in the treatment of periodontal diseases, with bacteria cell model Available online 28 April 2012 systems by using Langmuir monolayers. The insertion of the drug caused the surface pressure–area isotherms for a mixed protein–lipid monolayer to be shifted to higher lipid molecular areas, which was Keywords: the ﬁrst indication of the action