泛昔洛韦联合单磷酸阿糖腺苷治疗老年人带状疱疹临床疗效观察.pdf

海南医学2015年6月第26卷第11期 Hainan Med J, Jun. 2015, Vol. 26, No. 11 doi:10.3969/j.issn.1003-6350.2015.11.0604 ·临床经验· 泛昔洛韦联合单磷酸阿糖腺苷治疗老年人带状疱疹临床疗效观察 侯占英，刘 芳，黄 珍，刘万红 (深圳市龙华新区中心医院皮肤科，广东 深圳 518110) 【摘要】 目的 探讨泛昔洛韦联合单磷酸阿糖腺苷治疗老年人带状疱疹临床疗效。方法 90 例老年带状 疱疹患者随机分为两组各45 例，对照组予泛昔洛韦抗病毒以及营养神经等对症治疗，观察组联合应用单磷酸阿 糖腺苷治疗，比较两组患者的临床疗效及带状疱疹后遗神经痛(PHN)发生率。结果 观察组总有效率为93.3% ， 明显高于对照组的77.8% ，差异有统计学意义(P0.05) ；观察组患者止疱时间、止痛时间以及完全结痂时间、皮损 愈合时间均明显短于对照组，PHN 发生率明显低于对照组，差异均有统计学意义(P0.05) 。结论 泛昔洛韦联合 单磷酸阿糖腺苷治疗老年带状疱疹可有效抑制病毒复制，提高疗效，减轻神经炎症，降低PHN 发生率。 【关键词】 泛昔洛韦；单磷酸阿糖腺苷；带状疱疹；后遗神经痛 + 【中图分类号】 R752.1 2 【文献标识码】A 【文章编号】 1003—6350（2015 ）11—1686—03 Clinicaleffectoffamciclovircombinedwithvidarabinemonophosphateinthetreatmentofherpeszosterin elderlypatients.HOUZhan-ying,LIUFang,HUANGZhen,LIUWan-hong.DepartmentofDermatology,LonghuaNew DistrictCentralHospital,Shenzhen518110,Guangdong,CHINA 【Abstract】 Objective To explore the clinical effects of famciclovir combined with vidarabine monophos- phate in the treatment of herpes zoster in elderly patients. Methods Ninety elderly patients with herpes zoster were randomly divided into two groups with 45 patients in each group. The control group was treated with famciclovir and neurotrophic treatment, and observation group was treated famciclovir combined with vidarabine monophosphate. The clinical curative effect and postherpetic neuralgia (PHN) incidence in two groups were compared. Results The total effective rate in the observation group was 93.3%, which was significantly higher than 77.8% of the control group, and the difference was statistically significant (P0.05). The stop blistering time, analgesic time, ful