踏车运动对老年稳定型心绞痛患者的影响 - 中国康复医学杂志.pdf

ChineseJournalofRehabilitationMedicine, Dec.2011, Vol.26,No.12 ·临床研究· 踏车运动对老年稳定型心绞痛患者的影响 1 1,3 1 1,2 宋 红 邓景贵 陶 希 陈美娟 摘要 目的：探讨踏车运动对老年稳定型心绞痛患者的影响。 方法：141例老年稳定型心绞痛患者随机分成治疗组（68例）和对照组（73例），治疗组进行踏车运动和常规药物治 疗，对照组实行常规药物治疗，疗程4个月。使用放射免疫法检测实验前后血浆TXA2及免疫比浊法检测CRP、 LDL-C和HDL-C水平，监测实验过程中心率及血压变化，比较实验前后两者有无差异，并调查对比两组实验结束后 1月内心绞痛的发生率。 结果：治疗组有2例患者因不能耐受退出研究。对照组治疗后血浆CRP、TXA2和LDL-C水平分别下降58.30%、 45.64%和36.04%，HDL-C升高0.71%；治疗组治疗后血浆CRP、TXA2和LDL-C水平分别下降65.47%、38.29%和 36.18%，HDL-C升高2.11%；治疗组较对照组CRP下降明显，差异有显著性意义（P＜0.05）；但两组间TXA2、LDL-C 下降及HDL-C升高无明显差异（P＞0.05）。治疗前后两组间血压、心率变化无明显差异。两组治疗后均进行随访1 个月，治疗组（5/66）较对照组(16/73)心绞痛发生率明显减少，差异有显著性意义（P＜0.05）。 结论：踏车运动能明显降低老年稳定型心绞痛患者心绞痛发生率，其机制可能与降低CRP表达有关。 关键词 踏车运动；稳定型心绞痛；老年；C反应蛋白 中图分类号：R541.4,R493 文献标识码：A 文章编号：1001-1242（2011）-12-1140-04 The effect of treadmill exercise on the prognosis of elderly patients with stable angina pectoris/SONG Hong, DENG Jinggui, TAO Xi, et al.//Chinese Journal of Rehabilitation Medicine, 2011, 26(12): 1140— 1143 Abstract Objective: To study the effect of treadmill exercise on the prognosis of elderly patients with stable angina pecto- ris(SAP)patients. Method: One hundred and forty-one SAP patients were divided randomly into treadmill exercise group (68 cases) and control group (73 cases). The patients in treadmill exercise group received treadmill and conventional drug treatment for 4 months, and those in control group received routine drug treatment only. The differences on levels of plasma CRP, TXA2, LDL-C and HDL-C were defected between before and after experiment; the diversities of heart rate and blood pressure were monitored in experiment process and the differences between before and after experiment were compared; and the incidences of angina pectoris of two groups in 1 month after experiment were inve