谷胱甘肽防治疾病的研究进展 - 中国现代应用药学.pdf

谷胱甘肽防治疾病的研究进展  * 崔筱琳，王凤山 ( 山东大学药学院生化与生物技术药物研究所，济南 250012) 摘要：谷胱甘肽是由谷氨酸、半胱氨酸及甘氨酸组成的三肽，具有保护细胞、抗氧化、抗衰老、解毒等作用，几乎存在 于人体每个细胞中。虽然谷胱甘肽已经是治疗某些疾病的临床常用药，但近年来的研究显示体内谷胱甘肽水平及其还原 型和氧化型 2 种形式比例的改变与运动、神经、内分泌、循环、呼吸、消化、泌尿、生殖等系统疾病相关。本文总结了 近6 年来谷胱甘肽在细胞和动物试验及临床研究的最新进展，为谷胱甘肽老药新用研究开发及临床用药提供参考。 关键词：谷胱甘肽；应用；进展；疾病 中图分类号：R977.6 文献标志码：B 文章编号：1007-7693(2017)04-0631-06 DOI: 10.13748/ki.issn1007-7693.2017.04.034 Research Progress of Glutathione in the Prevention and Treatment of Diseases * CUI Xiaolin, WANG Fengshan (Institute of Biochemical and Biotech Drugs, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China) ABSTRACT : Glutathione is a tripeptide composed of glutamic acid, cysteine and glycine, which plays essential roles in cell-protection, anti-oxidation, anti-aging, detoxification, etc. Glutathione almost exists in every cell of the human body. As a common clinical medicine, it is used for treating several kinds of diseases. Recent studies have shown that the changes of GSH level and GSH/GSSG proportion are closely related with diseases in locomotor, nervous, endocrine, circulatory, respiratory, digestive, urinary and reproductive systems. The purpose of this review is to summarize the research progress of GSH in the prevention and treatment of diseases based on cell and animal experiments as well as clinical researches in recent six years so as to provide references for new drug development and clinical applications of glutathione. KEY WORDS: glutathione; application; progress; disease 谷胱甘肽是由谷氨酸、半胱氨酸及甘氨酸组 疗更加敏感[2-3] 。牙周炎术后相对于非手术牙龈内 成的三肽，有还原型(GSH)、氧化型(GSSG)2 种形 GSH 含量上升明显[4] 。另有大量研究表明，血浆 式。生理条件下占绝大多数的是活性状态的 GSH， 中 GSH 含量亦可能作为 I 型糖尿病并发肥胖症、 而非活性状态的 GSSG 仅占约 1%[1] 。GSH 广泛用