碱性成纤维细胞生长因子与肝素结合性质的研究进展3.pdfVIP

( ) ·2 14 · 中国病理生理杂志 　Chinese Journal of Pathophysiology 　2002 ,18 2 : 214 - 217 ( ) [文章编号] 　1000 - 4718 2002 02 - 0214 - 04 碱性成纤维细胞生长因子与肝素结合 性质的研究进展 1 2 1 1 熊 　盛 , 　林 　剑 , 　姚汝华 , 　宗敏华 ( 1华南理工大学生物工程系 ,广东 广州 510640 ; 2 暨南大学生物工程研究所 ,广东 广州 510632) Advances in the research of bF GF binding to heparin XION G Sheng1 ,L IN Jian2 , YAO Ru - hua1 , ZON G Min - hua1 ( 1 Dep artment of B iotechnology , South China University of Technology , Guangz hou 510640 , China ; 2 B ioengineering Research Institute of J inan University , Guangz hou 510630 , China ) 　　[ A Revie w] 　Basic fibroblast growth factor (bFGF) is a multi - potential growth factor whose biological activities depend on its receptor ’s intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. Heparin sulfate proteoglycans ( HSPGs) have been demonstrated to enhance or inhib it bFGF activity . The response elicited by HSPG is related to the relative concentrations and binding kinetics for bFGF of the various pools of HSPG. The type of cellular response might depend on the specific HSPG and FGF receptor expressed on the cell surface . The specific core protein of HSPG , and tissue specific differences in heparin sulfate modification result in altered bFGF regulation . 　　[ 关键词] 　成纤维细胞生长因子 ,碱性 ;肝素 　　　[ KEY WORDS] 　Fibroblast growth factor , basic ; Heparin 　　[ 中图分类号] 　Q507 　　　　　[文献标识码] 　A ( 　　碱性成纤维细胞生长因子 basic fibroblast growth