大承气汤灌肠法对脓毒症肠功能障碍患者的临床疗效.pdfVIP

提 要 目的：观察大承气汤灌肠疗法对脓毒症肠功能障碍患者的临床疗效。 方法：按照脓毒症诊断标准，采用前瞻性对照研究，选择2010年9月－2012年 4月收治于山东省中医院急诊科、ICU病房的60例脓毒症患者，采用随机数字表法， 随机分为两组。治疗组除西医综合治疗外，加用大承气汤灌肠，每日1次，对照组仅 采用西医综合治疗。以治疗前及治疗 7 天后 APACHEⅡ评分、白细胞计数(WBC)、C 反 应蛋白(CRP)为主要疗效指标。 结果：大承气汤灌肠能够减轻炎症反应：治疗组治疗一周后，较对照组WBC计数 有显著统计学差异(P0.05)；治疗一周后，较对照组C反应蛋白水平无显著统计学差 异(P0.05)，但治疗组治疗后C反应蛋白水平降低较对照组更明显；大承气汤灌肠能 够明显改善病情严重程度，治疗结束后，治疗组 APACHEⅡ评分低于治疗前，差异显 著（P0.05），对照组无明显变化。 结论：大承气汤灌肠疗法能改善脓毒症肠功能障碍；减轻脓毒症患者炎症反应； 减轻脓毒症肠功能障碍患者的病情严重程度。 关键词 脓毒症；大承气汤；灌肠疗法；肠功能障碍 Clinical efficacy of Dachengqi Decoction enema therapy on the sepsis with intestinal dysfunction Speciality: Internal Medicine of Traditional Chinese Medicine Author: Yao Kun Tutor: Prof.Wu Zuoli Abstract Objective: To study Clinical efficacy of Dachengqi Decoction enema therapy on the sepsis with intestinal dysfunction. Methods: In accordance with sepsis diagnosis standard,using a retrospective case-control study, select 60 Sepsis patients in the ICU of Affiliated Hospital of Shandong University of TCM from September 2010to April 2012, using random number table, randomly divided into two groups. The treatment group were offered Dachengqi Decoction enema treatment(once a day)based upon western routine treatment,while the control group received routine treatment only.APACHE Ⅱ score, WBC,CRP are selected as the main observing indexes for clinical effects. Results: Dachengqi Decoction enema treatment can remarkably improved severity and prognosis of sepsis.Compared with before treatment,APACHE Ⅱscore descend obviously in the treatment group(P0.05)while there was no significant difference in the control group. Dachengqi Decoction enema treatment can reduces