益肾降压颗粒对老年高血压病肾气亏虚自由基代谢的探究.pdfVIP

  提 要 目的：通过观察益肾降压颗粒对老年高血压病肾气亏虚证患者治疗前后的自由基 代谢的影响，探讨补肾益气法治疗老年高血压病的作用机制和靶点，为临床应用提供 理论依据。方法：选取符合标准的60例高血压病肾气亏虚证者随机分为2组，实验 组30例，对照组30例。实验组给予益肾降压颗粒口服联合西药常规降压，对照组给 予西药常规降压治疗。疗程8周。观察用药前后患者血压、症候积分及实验室指标的 变化。结果：实验组降压总有效率90%，组间比较无显著性差异（P0.05）；症候改 善总有效率93.3%，组间比较有显著性差异（P0.05）；实验组治疗后内皮四项及SOD、 GSH-px、LPO与治疗前比较有显著性差异（P0.05~0.01），组间比较有显著性差异 （P0.05~ 0.01）；治疗后hs-CRP与治疗前比较有显著性差异（P0.01），组间比 较无显著性差异（P0.05）。结论：益肾降压颗粒能明显改善老年肾气亏虚型高血压 患者的症状及体征，改善患者自由基代谢，保护血管内皮。 关键词 老年高血压病；肾气亏虚型；益肾降压颗粒；氧自由基；补肾益气。     Clinical Study on the kidneys and stepdown particlesin elderly hypertensive kidney disease of free radical metabolism Speciality: Traditional Chinese medicine and free radicals Author: Xu Xuemin Tutor: Li Rui Abstract Objective: Observe the kidneys and step-down particles for elderly hypertension patients with kidney deficiency syndrome before and after the treatment of free radicals metabolism, discusses the influence of the kidney treatments for elderly hypertension mechanism and targets, provides the theory basis for clinical application. Methods: 60 hypertensive patients with kidney deficiency syndrome randomly divided into two groups. Experimental group 30 patients and control group 30 patients. Experimental group received kidney particles combined with Western conventional antihypertensive treatment, the control group received conventional antihypertensive treatment western medicine ，for 8 weeks. Observe blood pressure、symptoms and laboratory changes before and