益肾降糖合剂治疗早期糖尿病肾病患者尿mAlbCr的临床探究.pdfVIP

提 要 目的：观察益肾降糖合剂治疗早期糖尿病肾病的临床疗效，并探讨尿微量白蛋 白与肌酐比值的测定对糖尿病肾病早期诊断的临床意义。方法：在基础降糖降压的 基础上，将临床诊断为早期糖尿病肾病患者随机分为两组，每组 30 例，对照组给 予金水宝胶囊治疗；治疗组给予益肾降糖合剂，两组均以4周为1个疗程，共2 个 疗程。结果：经临床观察，治疗组在改善本病的临床症状和体征方面优于对照组 （P0.05）；在改善尿微量白蛋白方面明显优于对照组（P0.05）；在改善超敏C 反 应蛋白、血液流变学方面优于对照组（P0.05）；并且在治疗过程中未发生不良反 应。结论：临床观察表明益肾降糖合剂治疗早期糖尿病肾病的疗效可靠，无明显不 良反应，显示出广阔的应用前景。观察 U-mAlb/UCr 比值能更准确的诊断出糖尿病 肾病患者早期肾损伤，在门诊DM患者中为患者定期检测尿mAlb／Cr，对防止和延 缓DN的发生具有实际临床意义。 关键词 早期糖尿病肾病；益肾降糖合剂；临床研究；尿微量白蛋白与肌酐比值 Clinical Research on the effect 0f Yishen-Jiangtang mixture on the Ualb/Cr in the patients with Early Diabetic Nephropathy Speciality：Internal medicine of Traditional Chinese Medicine Author ：Liu Weichao Tutor：Prof.Guo Baorong Abstract Objective ：To observe the Clinical efficacy of Yishen-Jiangtang mixture in treatment of Early diabetic nephropathy, and to discuss the Clinical significance of the determination of U-mAlb/UCr in early diagnosis of diabetic nephropathy.Methods ：At the basis of basic Lowering blood glucose and blood pressure, Divided the patients into two groups, who had been diagnosed as Early diabetic nephropathy ，each group had 30 cases. The patients in control group were treated with Jinshuibao Capsule, and treated with Yishen-Jiangtang mixture in treatment group . One process of treatment lasted for 4 weeks ,and two process were needed.Results ：By clinical observation ，treatment group had better results than the control group in improving the clinical symptoms and signs （P0.05 ）;in improving High-sensitivity C-reactive protein or in hemodynamics （P0.05 ）.There was no adverse reactions In the course of treatment.Conclusions ：Clinical observation showed that Yishen-Jiangtang mixture had reliable effect in treatment of Early di