益髓补血方为主联合ATRA治疗MDS-RA临床疗效的视察.pdfVIP

提 要 目的：观察益髓补血方为主联合全反式维甲酸（ATRA ）治疗骨髓增生异常综合 征RA型（MDS-RA ）的临床疗效及临床症状改善情况。 方法：将入选的40例骨髓增生异常综合征RA型患者随机分为2组，分别为实验组 和对照组，实验组20例，给予益髓补血方为主联合维甲酸治疗；对照组20例，给予维 甲酸治疗，两组均2个月为一疗程，两个疗程后对照观察两组患者治疗前后的临床疗 效。 结果：1.益髓补血方联合ATRA治疗可有效改善MDS-RA患者贫血、出血症状以 及外周血象，并降低外周血和骨髓中幼稚细胞百分比，疗效优于对照组（P0.05 ）。 2.治疗组患者的中医证候积分改善，明显优于对照组（P0.05 ）。 结论：采用益髓补血方为主联合维甲酸治疗MDS-RA ，可有效改善患者的临床症 状和血液学指标，在临床上值得进一步深入研究。 关键词 益髓补血方；全反式维甲酸；骨髓增生异常综合征；临床疗效 Clinical Research on Treating the Myelodysplastic syndrome-Refractory Anemia by Yisuibuxuefang Speciality：Internal Medicine of TCM Author ： Bao Yichao Tutor： Xu Ruirong Abstract Objective: observation on yisuibuxuefang recipe combined with All-trans retinotic acid(ATRA) in the treatment of Myelodysplastic syndromes-RA (MDS-RA) clinical effects, and a preliminary study on the therapeutic mechanism, to provide a basis for clinical use of drugs. Methods: met the inclusion criteria of 40 patients with myelodysplastic syndrome in patients with RA randomly divided into treatment and control groups, treatment group 20, invigorating the spleen and tonifying kidney plus combined with ATRA for reduction; control group of 20 cases, treated by simple use of ATRA.Two months were described as one period of treatment.After two periods，clinical effect was observed.Observation of clinical curative effect of two groups of patients before and after treatment and syndrome of traditional Chinese medicine to improve the situation, peripheral blood cell counts, percentage of naive cells from peripheral blood and bone marrow changes. Results: clinical observation: treatment group total effective rate 75.00%, controlled group total effective rate 55.00%, both Zhijian exists significa