益肾活血汤防治冠脉介入治疗术后再狭窄的探究.pdfVIP

提 要 目的：旨在探讨益肾活血汤防治冠状动脉介入治疗术后再狭窄的机制及临床作 用。方法：临床观察：将60例介入治疗成功的冠心病患者随机分为治疗组30例，对 照组 30 例，进行临床研究，观察其临床症状、复发心绞痛情况、心功能及对血脂、 血压、血糖、血清CRP的影响。动物实验：取家兔28只并建立冠状动脉再狭窄模型， 观察益肾活血汤对家兔ET、NO、sCD40L、Hcy的影响。结果：临床研究结果表明，益 肾活血汤能有效改善患者的临床症状；降低心绞痛复发率；提高左室射血分数；降低 血压、血脂、血糖及 CRP。动物实验结果表明，益肾活血汤能降低模型家兔的 ET 水 平、升高 NO 水平，调节二者的平衡；能够降低 sCD40L、Hcy 水平。结论：益肾活血 汤通过减少炎症反应、保护血管内皮功能、抗血小板聚集、抑制脂质过氧化，从而多 途径、多靶点防治介入治疗后再狭窄的发生。 关键词 益肾活血汤；介入治疗；再狭窄 The study on yishenhuoxuetang in Preventing and Treating Coronary Artery Restenosis after PCI Speciality: The combination of TCM with Western medicine (Internal Medicine Of Cardioangiology) Author: Guo Wen Tutor: Duan Xuezhong Abstract Objective:To probe the clinical effect and mechanism of Yishenhuoxuetang in preventing and treating coronary artery restenosis after PCI.Methods:60 coronary heart disease patients who had accepted PCI treatment successfully were randomly divided into 2 group,the treatment group(30 cases)and the comparative group (30 cases). To observe patient’s clinical symptoms,cardiac funtion, blood pressure,blood lipid,blood sugar,CRP.28 tamed hares were made into models of coronary restenosis.The effect of Yishenhuoxuetang on their ET、NO 、sCD40L、Hcy were observed.Results:Yishenhuoxuetang can effectively improve the patients’clinical symptoms,degrade the recurrence rate of angina,at the same time,it can reduce blood lipid 、blood suga 、blood pressure and CRP.The following findings are shown by animal experiment.It is found that Yishenhuoxuetang can improve the modles’NO 、sCD40L and Hcy level,reduce modles’ ET level.Conclusions:By reducing inflammatory reaction,preventing the function of endodermis,inhibiting platelet aggregation and the lipid hyperoxidation,Yishenhuo