益肾消癥汤治疗肾虚血瘀型子宫内膜异位症的临床探究.pdfVIP

提 要 目的：通过临床研究，观察益肾消癥汤对肾虚血瘀型子宫内膜异位症的治疗效果 并探讨其作用机理。方法：将 60 例子宫内膜异位症患者随机分为两组，中药益肾消 癥汤治疗组 30 例，西药丹那唑对照组 30 例。观察两组治疗前后症状、体征变化情况、 血清子宫内膜抗体（EMAb）、肿瘤坏死因子- a (TNF-a)、白细胞介素-6 （IL-6 ）、内分 泌（ E 、P 、PRL ）的变化及用药后的副反应情况。结果：益肾消癥汤组在调整月经 2 周期，提高性欲，增加受孕率等方面明显优于丹那唑组；在调整机体免疫功能方面， 降低 TNF-a 、IL-6 水平和 EMAb 的阳性率，与丹那唑组比较差异无显著性；在纠正 生殖内分泌紊乱方面，两组均能降低血 E2 、PRL ，组间比较差异无显著性，中药组升 高血 P ，与丹那唑组比较差异有显著性。结论：益肾消癥汤是治疗子宫内膜异位症的 有效方药，能有效改善患者的临床症状及体征，其作用机理可能是通过改善患者体内 免疫功能，调节女性内分泌水平，调整下丘脑－垂体－性腺轴功能而达到治疗目的。 关键词 子宫内膜异位症；益肾消癥汤；肾虚血瘀；临床研究 Clinical Study on the Effect of YiShenXiaoZheng Decoction In Treating Endometriosis Speciality:Gynecology of TCM, Endometriosis Tutor:Professor Wuxinhua Author:ZhaoXingLi Abstract Objective:To observe the effect of YiShenXiaoZheng Decoction (YSXZD) on endometriosis and to explore its mechanism. Methods: 60 patients due to ShenXuXueYu type were divided into two groups by random: 30 cases are settled as experiment groups,which are treated with YSXZD; 30 cases are settled as control group, which are treated with Danazol. Before and after treatment, the clinical symptoms, physical sign, the development of immunity, endocrine and deputy reaction were observed. Results: YSXZD is superior to Danazol in the area of regulating menstrual cycle, raising pregnancy rate, improving sexual desire;Adjust the body’s immune function,reducing TNF-a,IL-6 levels and the positive rate EMAb with danazol was no significant difference; In correcting the reproductive endocrine disorder,the both group could reduce blood E 、PRL which showed 2 , no significant difference,YSXZD group increased blood P,which was significantly d