益肾降压颗粒对老年男性高血压病肾气亏虚证患者IL-2、Leptin影响的探究.pdfVIP

提 要 本研究出自国家自然科学基金项目“补肾方药干预老年人高血压病肾气亏虚证性 激素受体表达及调控机制的研究”（No.。 目的：探讨中医肾气亏虚在高血压发病中的作用和机理，以及补肾法对老年男性 高血压病患者血清白介素2、瘦素、血压的影响和对临床症状的改善，为补肾法治疗 老年男性高血压病提供新的理论根据。方法：临床试验选择符合纳入标准的老年男性, 健康人组（20 人）、肾气亏虚组（20 人）、肝火上炎组（20 人）。分别用酶免法和放 免法测定三组的白介素2、瘦素水平观察统计。给予肾气亏虚组益肾降压颗粒治疗， 4 周为一个疗程，观察其治疗前后白介素2、瘦素水平及临床疗效。结果：临床研究 显示，肝火上炎组和肾气亏组较健康人组血清白介素2、瘦素水平均有上升，有统计 学意义。肾气亏虚组经益肾降压颗粒治疗后，不仅具有良好的降压、改善临床症状的 疗效，还使得治疗前后血清瘦素下降，有显著的统计学意义，值得临床广泛应用。结 论：益肾法是治疗老年人高血压病的重要法则，益肾降压颗粒是临床治疗老年男性高 血压病肾气亏虚证的有效方剂。 关键词 老年男性高血压病；肾气亏虚证；白介素2、瘦素；益肾降压颗粒；临 床研究 Research on the influence of YiShenJiangYa Granule on IL-2,Leptin of the elderly male patients with hypertension of Kidney Qi-deficiency syndrome Specialty:The study of cardiovascular diseases,Internal medicine of TCM Author:Han Xiaojie Tutor:Professor Guo Weixing Abstract The study comes from the national natural science foundation “qi-deficiency intervention filling kidney deficiency elderly hypertension syndrome sex hormone receptor case kidney-qi express and control mechanism research” . Objective:To observe the curative effect and primary mechanism of kidney Qi-deficiency syndrome in the morbidity of hypertension and the influence of filling kidney on IL-2,Leptin,blood pressure and the improvement of clinical symptoms and further to provide a new theoretical basis on the treatment of elderly primary hypertension through the TCM theory of filling kidney. Methods: In the clinical study, 60 elderly male patients of hypertension were divided into 3 groups:20cases in the health group,20 cases in the kidney qi-deficiency syndrome group and 20 cases in the liver-fire ascending group. Use enzyme immunoassay