益气温阳活血汤治疗糖尿病周围神经病变的探究.pdfVIP

提 要 目的：观察以益气温阳活血法为治则的中药对改善糖尿病周围神经病变(DPN)的 临床疗效并探讨其作用机制。方法：所有患者 60 名均确诊为糖尿病周围神经病变。 将病例随机分为 2 组，治疗组(30 例)服用益气温阳活血汤，对照组(30 例) 在同样条 件下给予甲钴胺胶囊 0.5mg，每天 3 次，口服。两组均以 40 天为 1 个疗程，共治 2 个疗程，然后评价两组神经传导速度。结果：经临床观察，治疗组有效率为 80%，对 照组的有效率为 63.3% 。治疗组在治疗前和治疗后的神经传导速度有显著差异 (p0.05),说明此法治疗是有效的。对照组治疗前和治疗后的神经传导速度有显著差异 (p0.01)，说明西药治疗也是有效的。治疗后治疗组与对照组比较神经传导速度也有 显著差异(p0.01) 。说明中药与西药治疗不尽相同。治疗组对改善临床症状，提高神 经传导速度方面优于对照组(p0.05) 。结论：益气温阳活血汤对治疗糖尿病周围神经 病变效果优于甲钴胺胶囊。同时证明以阳虚寒凝血瘀为糖尿病周围神经病变的病机， 利用益气温阳活血法治疗糖尿病周围神经病变具有可行性。 关键词：糖尿病周围神经病变 益气温阳活血 临床观察 The Clinical study on treatment of diabetic peripheral neuropathy with Yiqiwenyanghuoxue Decoction Speciality: Internal Medicine Of TCM Author:Cao Yue Tutor:Professor Xu Yunsheng Abstract Object:To observe the therapeutic efficacy of Yiqiwenyanghuoxue decoction in treating Diabetic Peripheral Neuropathy （DPN ）.Methods: 60 patients diagnosed DPN were randomly classified into two groups .30 patients in treated group were treated with Yiqiwenyanghuoxue decoction,others in control group were treated with Jiaguan grannules.Eighty days were a course of treatment. Result:Through observtion,there are significant effects of treatment on nerve conduction between pre-treatment and post-treatment in both TCM group(p0.05) and WM group(p0.01).In addition,there are also obvious difference between TCM and WM,indicating that the effects of TCM and WM were different.Conclusion:Yiqiwenyanghuoxue decoction has more curative effect than Jiaguan grannules in treating DPN,and it can prove that the freezing coldness from deficiency of yang and blood stasis is pathogenesis of DPN.To treat DPN with method of Yiqiwenyanghuoxue is feasibility.