益肾降压颗粒对老年人高血压病临床疗效研究和证候相关性探讨.pdfVIP

提 要 目的：通过对老年人高血压病肾气亏虚证与肝火上炎证的临床证候学研究，探讨 两种证候与老年人高血压病伴发疾病的相关性，研究两种证候与主要实验室指标的相 关性，以期揭示老年人高血压病肾气亏虚证与肝火上炎证之间的关系，为临床老年人 高血压病的辨证治疗提供新的思路。方法：选取年龄在 65-75 岁之间，1,2 级高血压 病并符合肾气亏虚证或肝火上炎证辨证标准的老年人高血压病患者，分为两组，每组 30 例。通过补肾方药（益肾降压颗粒）干预，观察两组患者主要实验室指标的变化、 血压及临床症状的改善程度。结果：老年人高血压病肾气亏虚证与肝火上炎证与高血 压病伴发疾病相关性无明显差异；老年人高血压病肝火上炎证患者与甘油三酯（TG ） 有相关性；益肾降压颗粒能调节老年人高血压病肾气亏虚证及肝火上炎证的血压水平 及改善临床症状，对相关实验室指标也有明显改善作用。结论：1.老年人高血压病肾 气亏虚证与肝火上炎证患者，与糖尿病、冠心病、高脂血症、脑血管病等伴发疾病无 明显相关。2.老年人高血压病患者是否存在肝火上炎证与临床化验指标 TG 有相关性， 与 TC、HDL-C 、LDL-C 、BS 无相关性。3.益肾降压颗粒对老年人高血压病肾气亏虚 证及肝火上炎证血压的控制起到了良好的效果，并能显著改善两组证候病人的临床症 状。4. 肾气亏虚是老年人高血压病的基本病机，其病机本质上是本虚标实，本虚即为 肾气亏虚，标实为肝火上炎。 关键词 老年人高血压病；临床疗效；肾气亏虚证；肝火上炎证；相关性 Research on the Clinical Effect of Yi Shen Antihypertention Granule Treating Elderly Hypertension Patients and Discussion of the Syndrome Correlation Speciality:The study of cardiovascular diseases,Internal medicine of TCM Author:Kan Jun Tutor:Professor Guo Weixing Abstract Objective: By research on senile hypertension syndrome of deficiency of kidney Qi and study on clinical syndromes of anger inflammation card patients，to explore the relationship between the two syndromes with elderly hypertension associated disease，to study the two syndromes and main laboratory indexes in order to reveal the relationship between the elderly hypertension kidney deficiency syndrome and the anger inflammation card, to provide new ideas of dialectical treatment of clinical hypertension of the elderly. Methods: Select age between 65-75 years old, 1,2 hypertension and the kidney deficiency syndrome or anger inflammation card patients. Divide the patients into two groups, each group of 30 cases. By using invigorate kidney qi-deficiency (Yi Shen Jiang ya granule) , observe the two sets of change of laboratory indices in patients with clinical symptoms, blood pressure and Clinic