益血方治疗肿瘤相关性贫血的临床探究.pdfVIP

提 要 目的：恶性肿瘤的发病率逐年升高，已经成为当今严重危害人类健康的常见疾病。 贫血是恶性肿瘤常见的并发症之一，不仅使患者的生活质量下降，而且影响肿瘤的临 床治疗。脾肾不足，气血亏虚是其重要病机，本研究以健脾益肾、补气生血为治法， 应用中药汤剂“益血方”，观察中西医结合治疗肿瘤相关性贫血的疗效。方法：选择 60例Ⅲ～Ⅳ期恶性肿瘤伴发贫血患者，随机分为观察组和对照组，其中观察组30例， 对照组30例，两组均给予化疗，观察组在化疗的基础上服用益血方。连续观察两个化 疗周期后，比较两组治疗前后症状、生活质量、卡氏评分、血红蛋白水平、体重、免 疫功能、毒副反应程度等情况。结果：益血方治疗肿瘤相关性贫血，可改善大部分临 床症状，提高生活质量，升高血红蛋白水平，稳定并增加体重，提高机体免疫功能， 减轻毒副反应。但在减小和稳定病灶方面与单纯化疗组相比无显著性差异，两组对肝、 肾功能的损害都不明显。结论：益血方能显著提高患者的血红蛋白水平，并且具有增 效减毒作用，是治疗肿瘤相关性贫血的有效方法之一。 关键词 益血方；肿瘤相关性贫血；化疗；中西医结合； Clinical Study on Cancer-related Anemia Treated by ‘Yi xue fang Prescription’ Speciality: Internal Medicine of Integrated TCM and Western Medicine Author: Chen Guifeng Tutor: Liu Xiurong Abstract Objective: The incidence of cancer increased year by year, has become a serious hazard to human health diseases. Anemia is a common complication of cancer, not only the quality of life of patients and the clinical treatment of cancer. Spleen and kidney deficiency is an important pathogenesis. In this study, ‘Jian pi yi shen and bu qi sheng xue’is one of the most important principle of treatment, based on it, we choose ‘Yi xue fang prescription’ to study the combined curative effect of Chinese medicines and chemotherapy on cancer-related anemia. Methods: 60 subjects with Cancer-related Anemia were randomly divided into two groups, 30 patients in the observed group were administered with ‘Yi xue fang Prescription’ and chemotherapy, 30 patients in the control group with chemotherapy. Objective effects and the changes of subjective symptoms were studied during two periods of treatment. Results: After two cycles of treatment, the subjective symptoms、KPS 、body weights 、immune parameters were all significantly improve in the control one. But there was no difference between two groups