蛋白质0010001（Protein 0010001）.docVIP

蛋白质0010001（Protein 0010001） A-level structure of protein The A-level structure of protein (primary structure) is the order of amino acid residues in protein polypeptide chains (sequence), which is also the most basic structure of proteins. It is determined by the order in which genetic codes are sequenced. All kinds of amino acids in the order of genetic code, through peptide bonds linked to become polypeptide chain, so the peptide bond is the protein structure of the primary key. So far, about 1000 proteins have been identified in the A-level structure, such as insulin, pancreatic ribonucleic acid enzymes, trypsin and so on. Protein A-level structure determines the protein two-and three-level advanced structure, the tens of billions of natural proteins have their own special biological activity, determine the biological activity of each protein structure characteristics, first of all, the amino acid sequence of peptide chain, because of the special side chains of the 20 amino acids that comprise the protein, the physical and chemical properties and spatial arrangement of the side chain groups are different, and when they are combined according to various sequence relationships, a variety of spatial structures and protein molecules with different biological activities can be formed. II. Spatial structure of proteins The polypeptide chains of protein molecules are not linearly stretched, but folding and coiled constitute a relatively stable spatial structure. The biological activity and physical and chemical properties of proteins are mainly determined by the completeness of the spatial structure, so it is not possible to fully understand the biological and physical properties of protein molecules by only measuring the amino acid composition and sequencing of protein molecules. such as globular proteins, which are found in plasma, globulin, hemoglobin, enzymes, etc.) and fibrous proteins (keratin, collagen, myoglobin, fibrin, etc.), the former soluble in water, the l