降酶丸治疗慢性乙型病毒性肝炎的临床探究.pdfVIP

提 要 目的：以慢性乙型病毒性肝炎患者为研究对象，观察降酶丸对其临床疗效的影 响，探讨其保肝降酶的机制，为临床应用提供可靠的依据。 方法：选符合入选标准的慢性乙型病毒性肝炎患者 94 例随机分为两组,治疗组 48 例给予降酶丸治疗，对照组 46 例给予天晴甘平治疗，两组均以 3 个月为一疗程， 分别观察治疗前后的症候变化，对症状、体征进行记录评分，并检测疗效指标：肝 功能指标（谷丙转氨酶(ALT)、谷草转氨酶( AST)、γ-谷氨酰转肽酶(GGT)、总胆红 素(TBiL)、直接胆红素(DBiL)、总胆汁酸( TBA)、白蛋白(ALB) 、白球比(A/G )、 胆碱酯酶 （CHE））、血清病原标志物指标及肝脾彩色多普勒检查 （主要观察肝脏大小、 表面被膜、边缘、实质回声、脉管、门静脉宽度、脾脏大小等情况），同时监测血、 尿、便常规，心电图、肾功能等安全性指标，进行统计学分析，判断疗效及用药安 全性。 结果：治疗 3 个月后，两组在综合疗效、中医症候疗效、恢复肝功能等主要指 标方面均有临床疗效，但降酶丸在改善中医症候疗效方面优于对照组，与天晴甘平 组比较有统计学差异（P0.01）。 结论：降酶丸能有效治疗慢性乙型病毒性肝炎，改善临床症状，保肝降酶，值 得进一步深入研究和临床推广应用。 关键词 降酶丸；保肝降酶；症候疗效；慢性乙型肝炎；临床研究 The Clinical Study of Jiangmei Pill on Chronical Virus B Hepatitis Speciality: Digestive system disease. Internal Medicine of TCM Author: Wang Yipeng Tutor: Professor Xie Xushan Abstract Objective: With chronic hepatitis B patients in this study, the clinical efficacy observed JiangMei pill, and to explore the liver reducing enzyme, the mechanism of resistance to the process of liver fibrosis, for clinical applications provide a reliable basis. Methods: The election that met the inclusion criteria of chronic hepatitis B patients with 94 cases were randomly divided into two groups, whil 48 cases treatment group will be given JiangMei pill treatment, control group 46 cases will be given Tianqingganping treatment, the two groups are a three monthtreatment, and symptom changes were observed before and after treatment, symptoms, signs record score, and detection efficacy of indicators: indicators of liver function (alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl GGT (GGT), total bilirubin (TBiL and), direct bilirubin (DBiL), albumin (ALB), total bile acid (TBA), albumin (ALB), the white ball ratio (A/G), cholinesterase (CHE)), serum pathogenic markers in