隔姜蒜督灸治疗强直性脊柱炎和对Ⅰ-型胶原C末端肽影响的临床研究.pdfVIP

提 要 目的：观察隔姜蒜督灸治疗强直性脊柱炎的临床疗效及不良事件发生情况，分析 比较隔姜蒜督灸与隔姜督灸对 I-型胶原 C 末端肽（CTX-I）的影响，为 AS 的治疗提 供新方法。 方法：筛选60例强直性脊柱炎患者，随机分为治疗组与对照组。治疗组采用隔姜 蒜督灸治疗，对照组采用隔姜督灸治疗。每组30例患者，治疗三次，每月一次，分别 观察患者治疗前后症状、体征和I-型胶原C末端肽（CTX-I）的变化。 结果： 1.两种治疗方法均可有效改善临床症状（P﹤O.01），治疗组总有效率为 93.3%；对照组总有效率为80%，治疗组疗效优于对照组。 2.治疗前后两组症状积分组内比较均有显著性差异(P﹤O.01)；治疗后组间 比较有显著性差异(P﹤0.05)，治疗组优于对照组。 3.两种治疗方法治疗前后体征积分组内比较均有显著性差异(P﹤O.05)，治疗后 两组间比较无差异(P﹥0.05)。 4.治疗组治疗前后I-型胶原C末端肽组内比较有显著性差异(P﹤0.01)，对照组治 疗前后I-型胶原C末端肽组内比较有显著性差异（P﹤0.01），治疗后组间比较有显著 性差异（P﹤0.05），治疗组优于对照组。 5.观察期间治疗组和对照组均无不良事件发生。 结论： 1.隔姜蒜督灸和隔姜督灸均可改善强直性脊柱炎患者的临床症状、体征。 2.隔姜蒜督灸和隔姜督灸对I-型胶原C末端肽均具有改善作用。 3.隔姜蒜督灸不良事件发生少，是治疗强直性脊柱炎安全有效的方法之一，值得 临床推广应用。 关键词 隔姜蒜督灸；强直性脊柱炎；I-型胶原 C 末端肽（CTX-I）；不良事件； 临床研究 The Clinical Research of Du-Moxibustion across Ginger and Garlic on Significance of C-telopeptides of Type Ⅰcollagen (CTX-I) Influence in Treating AS Speciality：Acupuncture and Moxibustion Author ：Wang JunYang Tutor ： Zhang Tong Abstract Object: To observe the clinical curative effect and adverse events of Du-Moxibustion across ginger and garlic in treating ankylosing spondylitis (AS), analyse the impact evaluation of the sacroiliac joint Significance of C-telopeptides of Type Ⅰcollagen (CTX-I) scans , and to explore a new way and to provide imaging basis for treatment of AS. Method: 60 patients with AS were divided into treatment group and control group at random. 30 cases were treated with Du-Moxibustion across garlic and ginger therapy,while the other 30 cases were treated with Du-Moxibustion across ginger therapy. Each group were treated 3 times in all and were treated once a month. The changes of symptom, sign and sacr