AMI患者治疗前后血浆Hcy和ET检测的临床意义.pdfVIP

--— — 214．．—— 杂志2008年第21卷第3期J of Radioimmun010~2008 ． 21 f3 AMI患者治疗前后血浆Hcy和 ET检测的临床意义 江苏省连云港市第二人民医院心内科(222023) 周 峰 摘要 目的：探讨了急性心肌梗死(AM1)患者治疗前后血浆Hey和ET水平的变化。方法：应用放免法测 定了33例AMI患者的血浆Hey和ET含量，并与30名正常健康人作比较。结果：AMI患者在治疗前后血浆 Hey和ET水平非常显著地高于正常人组(P0．01)，并且呈显著的正相关(r=0．5988，P0．01)。经一个月 治疗后血浆Hey水平与正常人比较无显著性差异(P0．05)，而血浆ET水平与正常人比较仍有显著性差异 (P0．05)。结论：检测AMI患者血浆Hey和ET水平的变化对临床观察预后有重要的临床价值。 关键词 急性心肌梗死 同型半胱氨酸 内皮素 Clinical Significance of Measurement of Changes of Plasma Hcy and ET Levels After Treatment in Patients with Acute Myocardial I nfarction(AM I) Zhou Feng I．,ianyunC．ang Secondpeople’s Hospital(222023) Abstract Objective To explore the clinical significance of changes of plasma Hey and ET levels in pafienm witll AM]after treatment．Methods Plasma Hcy and ET leve~Were measured with RIA in 33 patients with acute myocardial infarction both before and after treatment as well as in 30 controls．Results Plasma Hey and ET levels Were significantly higher in the AM]paffents than those in the contro~before treatment and the levels were4mutually positively cor~lated(P0．01)．After treatment for one month，the plasma Hey level in the patients were not much differentfrom those in the contmh(P0．05)，but plasmaET levels，though dropped markedly remained sisnitacantly higher(P0．05)．Conclusion Changes ofplasma Hey and ET levels after treatment misht be of prognostic importance in patients with acute myocardial infarction． Key Words acute myocardial infarction(AMI)，homoeystcinc(Hey)，endothelin(ET) 同型半胱氨酸(homoeystcinc，Hey)是一种含巯基的氨基 1．2．4 统计学处理：所测数据以 ±s表示，组间比较采用t 酸，为蛋氨酸代谢的中间产物。近年来颇受临床和科研工作 检验，相关分析采用直线回归。 者的关注”J。内皮素(Endothelin，ET)是一种具有强大的收 缩血管和促进平滑肌增殖作用的肽素物质