亲环素a与肿瘤相关性的研究进展 - tumor.pdf

928 　　肿瘤2013 年10 月第33 卷第10 期　TUM OR Vol. 33, October 2013 DOI: 10.3781/j .issn.1000-7431.2013.10.015 Copyright© 2013 by TUM OR Review 综述 · 亲环素A与肿瘤相关性的研究进展 1, 2 1 冯文华 ，辛　彦 1. 中国医科大学附属第一医院肿瘤研究所胃肠肿瘤病理研究室，普通外科研究所肿瘤病理研究室, 辽宁 沈阳　 110001；2 . 辽宁省计划生育科学研究院生殖健康重点实验室辽宁沈阳　110031 [摘要]　亲环素A （cyclophilin A ，CypA ）是亲环素家族中发现最早、含量最丰富、研究最深入的一员，是细胞 内免疫抑制剂环孢素A （cyclosporin A ，CsA ）的主要受体。其具有肽基脯氨酰顺反异构酶 （peptidyl-prolyl cis- trans isomeras ，PPIase ）的活性和分子伴侣功能，能辅助细胞内蛋白质的正确折叠，参与免疫抑制，介导炎性反应 和参与氧化应激应答等多种生物学功能。近期的研究发现，CypA 在多种恶性肿瘤中高表达，具有促进癌细胞增殖、 抑制细胞凋亡、介导侵袭转移等作用，未来可能成为某些恶性肿瘤诊断和治疗的新靶点。 [关键词]　肿瘤；亲环素类A ；信号转导；CD147 [中图分类号]　R735.2 [文献标志码] A [文章编号]　1000-7431 (2013) 10-0928-07 Progress in research on cyclophilin A and malignant tumors FENG Wen-hua1, 2 , XIN Yan1 1. Gastrointestinal Tumor Pathology Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China; 2. Key Laboratory of Reproductive Health, Liaoning Province Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China [ABSTRACT]　CypA (cyclophilin A), the main intracellular receptor of immunosuppressant CsA (cyclosporin A), is the first discovered and most abundant one in cyclophilin family and has been studied in-depth. CypA has PPIase (peptidyl-prolyl cis-trans isomerase) activity and molecular chaperone functions which enable it playing a role in correct protein folding. CypA also involves in a variety of biological functions such as immune suppression, inflammatory response, and oxidative stress response. Recent studies have found that CypA was overexpressed in many malignant tumo