小檗碱调节血糖血脂代谢紊乱机制研究进展advances of - 药学学报.pdfVIP

药学学报 Acta Pharmaceutica Sinica 2010, 45 (6) : 699704 ·699 · 小檗碱调节血糖血脂代谢紊乱机制研究进展 * 宁, 李彩娜, 环 奕, 申竹芳 ( 中国医学科学院、北京协和医学院 物研究所, 北京 100050) 摘要: 小檗碱是从中药黄连等中提取的异喹啉类生物碱, 长期以来用于治疗腹泻及消化道感染。近年来, 陆 续有报道小檗碱可对糖尿病代谢紊乱状态发挥有益作用。其机制研究亦涉及疾病发生的多个环节, 包括调节血 胆固醇、甘油三酯; 降低血糖; 改善胰岛素抵抗状态; 影响胰岛 细胞功能等。 关键词: 小檗碱; 糖尿病; 胰岛 细胞 中图分类号: R285 文献标识码:A 文章编号: 05 13-4870 (2010) 06-0699-06 Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders * SHEN Ning, LI Cai-na, HUAN Yi, SHEN Zhu-fang (Institute of Materia Medica, Chinese Academy of M edical Sciences Peking Union M edical College, Beij ing 100050, China) Abstract: Berberine, an isoquinoline alkaloid isolated from some Chinese medicinal herbs such as Cop tidis rhizoma, has been used for the treatment of diarrhea and other gastrointestinal infections as an antibacterial drug in Chinese medicine. In recent years, it was reported to have beneficial effects on the metabolism disorders states of diabetes. The mechanisms involve many aspects of the diabetes, including regulating the blood cholesterol and triglyceride, lowering blood glucose, ameliorating the insulin resistant state and influencing the function of the pancreatic cell. Key words: berberine; diabetes; pancreatic cell 中药黄连在中国已有几千年的应用历史, 主要 增高、代谢紊乱。增高的血脂引起脂质在脂肪组织外 用于治疗消化道感染。小檗碱 (berberine) 是中药黄 积聚, 引起氧化应激、炎症反应, 导致外周胰岛素抵 连的主要生物碱。近年来发现其 理作用广泛,