黑地黄丸治疗慢性肾衰脾肾两虚证的临床疗效和成本效果分析.pdfVIP

提 要 目的：研究古方黑地黄丸治疗慢性肾功能衰竭脾肾两虚兼湿浊证，评价其经济学 价值，为临床应用提供客观依据。方法：1.采用前瞻性、随机、阳性药物平行对照方 法，共纳入160例病人，随机分为试验组80例和对照组80例，分别服用黑地黄丸和 肾康宁，连续口服 2个月，结束疗程。观察和检测两组治疗前后临床症状、肾功能及 血RBC、HGB的变化情况。2.将两组进行成本-效果分析。结果：1.试验组黑地黄丸总 有效率为 80.77%，显著优于对照组肾康宁 62.34%（p＜0.01）。2. 黑地黄丸组和肾 康宁组一个疗程人均成本分别为111.6元、189元，其成本效果比 （C/E）分别为1.38、 3.03，相对于肾康宁组，黑地黄丸组的增量成本效果比（△C/△E）为-4.20，因此黑 地黄丸为更经济方案。3. 两组治疗过程中均未发生不良反应。结论：黑地黄丸是治 疗慢性肾功能衰竭脾肾两虚兼湿浊证的安全、有效、经济、合理的方剂，符合药物经 济学原则。 关键词 黑地黄丸；慢性肾功能衰竭；临床疗效；成本-效果分析 HeidiHuang pill treat chronic renal failure with both spleen and kidney deficiency clinical efficacy and cost- effectiveness analysis Specialty:The study of Kidney Diseases. Internal Medincine of Traditional Chinese Medincine Author:Wang Fang Tutor:Professor Zhang Fa-rong Abstract Objective: To study the ancient prescription HeidiHuang pill in treating chronic renal failure with both spleen and kidney deficiency and dampness, evaluating its health economics, to provide an objective basis for clinical application.Methods: 1.Take the method of prospective, randomized, parallel positive drug control to observe 160 cases of the CRF patients, were randomly divided into 80 cases of the test group and 80 cases of the control groups, the test group were treated HeidiHuang pill and the control group were treated ShenkangNing, continue taking 2 months, the course of treatment being over orally. Observe clinical symptoms and detection the level of renal function and Red blood cell and Hemoglobin of the two groups.2.Two groups is carried out Cost-effectiveness analysis. Results: 1.The total efficiency of test group is 80.77%, which is significantly better than the control group 62.34% (p ＜0.01).2.The average cost of a course of HeidiHuang pill and Shenkan