the swiss-prot protein sequence data bank and its supplement trembl in 1999（swiss-prot蛋白质序列数据银行及其补充trembl在1999年）.pdfVIP

 1999 Oxford University Press Nucleic Acids Research, 1999, Vol. 27, No. 1 49–54 The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999 Amos Bairoch* and Rolf Apweiler1 Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland and 1The EMBL Outstation—The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK Received October 7, 1998; Revised and Accepted October 28, 1998 ABSTRACT Annotation In SWISS-PROT two classes of data can be distinguished: the SWISS-PROT is a curated protein sequence database core data and the annotation. For each sequence entry the core which strives to provide a high level of annotation data consists of the sequence data; the citation information (such as the description of the function of a protein, its (bibliographical references) and the taxonomic data (description domain structure, post-translational modifications, of the biological source of the protein), while the annotation variants, etc.), a minimal level of redundancy and high consists of the description of the following items: level of integration with other databases. Recent (i) Function(s) of the protein developments of the database include: cross-refer- (ii) Post-translational modification(s). For example carbohy- ences to additional databases; a variety of new drates, phosphorylation, acetylation, GPI-anchor, etc. documentation files and improvements to TrEMBL, a (iii) Domains and sites. For exam