4AD与双烯之战（4AD battle with diene）.docVIP

4AD与双烯之战（4AD battle with diene） Biological manufacturing and resource biology of steroids in our country: binary and 4AD game key words: biological manufacturing; Resource biology; Diene (the important intermediates of diosgenin chemical degradation - 5, 6 - pregnenol) versus 4AD (androstenedione biodegradable by plant sterols)????????????????????????????????????????????????????????????????????????? ?? Yang Shunjie??? Sichuan? Chengdu steroid hormone drugs in China (mainly including corticosteroids, sex hormones and the pill) production, began research and development since 1958, the same as in the initial stage of the European and American countries used to plant source sex yam diosgenin as the starting material, through chemical synthesis and biological manufacturing (microbial 11 - hydroxylation and/or 1, 2 - dehydrogenation, and 16 hydroxylation, in recent years, 15 hydroxylation and nine hydroxylation of 4 AD) production corticoid hormones and the new type of birth control pills (59 years total synthesis of steroid apis to realize industrialization) has a rapid development. Since the 1990s, the world has been in a golden age of steroid hormones - sales have increased by 10-15% annually. Domestic only the glucocorticoid pharmaceutical industry 32, the approval of 110; The consumption of diosine is 2000 tons per year, and the sales revenue is ten billion yuan, and the domestic share is 5%. So the steroid hormone drugs the rigid demand of the market in the forest of world medicine rock-solid indispensable say, only based on four big corticoid API (cortisone/prednisone, hydrocortisone/prednisolone) in 2007, according to the tenth edition of the Brok microbiology data provided by the global annual production of more than 800 tons; China chengdu pengzhou 2001 national conference on steroid hormone drugs, tianjin medical yan-chang lu report at that time, Chinas four major basic corticoid API production has reached 130 tons, accounting for one-third of global productio